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货号： bs-6675R 基本售价： 1380.0 元 规格： 100ul
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-6675R
- 英文名称
- KCNN4
- 中文名称
- 钙激活钾通道蛋白4抗体
- 别 名
- hIKCa1; IK1; IKCa1; Intermediate conductance calcium activated potassium channel protein 4; Intermediate conductance calcium-activated potassium channel protein 4; KCa3.1; KCa4; KCNN 4; Kcnn4; KCNN4_HUMAN; Potassium intermediate/small conductance calcium activated channel, subfamily N, member 4; Putative Gardos channel; SK4; SKCa 4; SKCa4.
- Specific References (1) | bs-6675R has been referenced in 1 publications.[IF=3.23] Zhang, Panshi, et al. "Inhibition of SK4 Potassium Channels Suppresses Cell Proliferation, Migration and the Epithelial-Mesenchymal Transition in Triple-Negative Breast Cancer Cells." PLOS ONE 11.4 (2016): e0154471. IHC-P ; Human.PubMed:27124117
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul
- 研究领域
- 细胞生物 神经生物学 通道蛋白 细胞表面分子
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig,
- 产品应用
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 50kDa
- 细胞定位
- 细胞膜
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human KCNN4:325-427/427
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin.
Function:
Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin.
Subunit:
Heterotetramer of potassium channel proteins (Probable). Interacts with MTMR6.
Subcellular Location:
Membrane; Multi-pass membrane protein.
Tissue Specificity:
Widely expressed in non-excitable tissues.
Post-translational modifications:
Phosphorylation at His-358 by NDKB activates the channel, and conversely its dephosphorylation by PHPT1 inhibits the channel.
Similarity:
Belongs to the potassium channel KCNN family. KCa3.1/KCNN4 subfamily.
SWISS:
O15554
Gene ID:
3783
Database links:Entrez Gene: 3783 Human
Entrez Gene: 16534 Mouse
Entrez Gene: 65206 Rat
Omim: 602754 Human
SwissProt: O15554 Human
SwissProt: O89109 Mouse
SwissProt: Q9QYW1 Rat
Unigene: 10082 Human
Unigene: 9911 Mouse
Unigene: 44212 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
- 产品图片
Sample:
Brain (Rat) Lysate at 40 ug
Heart (Rat) Lysate at 40 ug
Primary: Anti-KCNN4 (bs-6675R) at 1/300 dilution
Secondary: HRP conjugated Goat-Anti-rabbit IgG (bs-0295G-HRP) at 1/5000 dilution
Predicted band size: 50 kD
Observed band size: 48/42 kD