BV605 Mouse Anti-Human CD335 (NKp46)
货号:
743710 基本售价:
9000.0 元 规格:
EA
产品信息
概述货号 | 743710 |
描述 | The 9E2/Nkp46 monoclonal antibody specifically binds to CD335. CD335 is also known as the Natural killer cell p46-related protein (NKp46) and the Natural cytotoxicity triggering receptor 1 (NCR1). CD335 is a 46 kDa type I membrane glycoprotein that is expressed on resting and activated NK cells. Its extracel lular region contains two C2-type, Ig-like domains. The transmembrane domain contains a positively charged amino acid (Arg) which could be involved in stabilizing the association with CD3ζ. Its intracellular region does not contain immunoreceptor tyrosine-based activating motifs (ITAM), but it is linked to intracytoplasmic transduction machinery by its association with CD3ζ and FcεRIγ adaptor proteins. CD335 along with NKp30 and NKp44 are referred to as natural cytotoxicity receptors (NCR). These receptors play very important roles in cells that kill virus-infected target cells, tumor cells and MHC-class I-unprotected cells. |
别名 | NCR1; NK-p46; hNKp46; LY94; Natural cytotoxicity triggering receptor 1 |
同种亚型 | Mouse BALB/c IgG1, κ |
反应种属 | Human (Tested in Development) |
性能供应商 | BD Pharmingen |
免疫原 | Human NKp46 Recombinant Protein |
存放说明 | Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated with BD Horizon BV605 under optimal conditions that minimize unconjugated dye and antibody.
|
存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide. |
浓度 | 0.2 mg/ml |