BUV395 Mouse Anti-Human CD91
货号：
743862 基本售价：
9000.0 元 规格：
EA
产品信息
概述| 货号 | 743862 |
| 描述 | The A2MR- α 2 monoclonal antibody specifically reacts with a 600 kDa, type I membrane single protein, also known as the α 2 Macroglobulin ( α 2M) receptor/low density lipoprotein receptor-related protein 1 (LRP-1). Reported to be an endocytic receptor involved with intracellular signalling, lipid homeostasis, clearance of apoptotic cells, and α 2 Macroglobulin mediated clearance of secreted amyloid precursor protein found in Alzheimer patients. The single chain receptor undergoes cleavage, shortly after synthesis, into the 85 kDa transmembrane β chain that non-covalently binds to the extracellular 500-515 kDa a chain. It has a broad cellular distribution, but in the hematopoietic system it is expressed on monocyte lineage cells. α 2M/LRP-1 mediates endocytosis of a variety of ligands including α 2M-proteinase complexes, plasminogen activators in complex with plasminogen activator inhibitor, or Pseudomonas Exotoxin A. Ligand binding to α 2M/LRP-1 is followed by rapid transport of the ligand to lysosomes for degradation. |
| 别名 | A2MR; APOER; APR; IGFBP3R; TGFBR5; LRPA; LRP1 |
| 同种亚型 | Mouse BALB/c IgG1, κ |
| 反应种属 | Human (Tested in Development) |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Purified Human α2 Macroglobulin |
| 存放说明 | Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated with BD Horizon BUV395 under optimal conditions that minimize unconjugated dye and antibody.
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| 存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide. |
| 浓度 | 0.2 mg/ml |
