BV605 Mouse Anti-Human CD119
货号：
743028 基本售价：
9000.0 元 规格：
EA
产品信息
概述| 货号 | 743028 |
| 描述 | The GIR-208 antibody recognizes the extracellular region of CD119 which is also known as the alpha chain subunit (80-95 kDa glycoprotein) of the human interferon- γ receptor (IFN- γRα ). The functionally active-form of the human IFN- γ receptor consists of two (or more) subunits, with IFN- γRα responsible for IFN- γ binding and both the IFN- γRαandβ chains required for the transduction of biologic responses. The IFN- γreceptorα chain (CD119) is expressed on the surface of most human cells (except mature erythrocytes) including monocytes, macrophages, T cells, B cells, NK cells, neutrophils, fibroblasts, epithelial cells, and endothelium. Binding of 125I-labeled GIR-208 antibody to IFN- γRα + cells is reported to be specifically inhibited in the presence of excess IFN- γ . GIR-208 does not cross react with IFN- γ as tested by ELISA. The ability of this antibody to bind to IFN- γ receptors of species other than human has not been determined. The immunogen used to generate this hybridoma was human IFN- γRα purified from human placenta. The GIR- 208 has been reported to block the binding of 125I-human IFN- γ to IFN- γRα + cells as well as purified, soluble human IFN- γRα . GIR-208 is a neutralizing antibody that has been shown to neutralize the anti-viral activity of IFN- γ on WISH cells in a dose-dependent fashion. |
| 别名 | IFN- gamma receptor alpha chain |
| 同种亚型 | Mouse IgG1, κ |
| 反应种属 | Human (Tested in Development) |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human IFN-γRα |
| 存放说明 | Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated with BD Horizon BV605 under optimal conditions that minimize unconjugated dye and antibody.
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| 存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide. |
| 浓度 | 0.2 mg/ml |
