BV421 Mouse Anti-Human CD284 (TLR4)
货号:
743392 基本售价:
9000.0 元 规格:
EA
产品信息
概述货号 | 743392 |
描述 | The HTA125 monoclonal antibody specifically binds to the human Toll-like receptor 4 (TLR4), also known as CD284. Toll-like receptors (TLR) are type I transmembrane proteins characterized by an extracellular domain containing leucine-rich repeats and a cytoplasmic domain similar to IL-1R family. In humans, ten TLR have been identified so far. The TLR family acts as a pattern-recognition receptor that is an essential component of pathogen recognition and innate immunity. TLR4 has been identified as the receptor for Gram-negative bacterial lipopolysaccharide (LPS). TLR4 mRNA expression has been found in spleen, placenta, ovary, intestine and lung. Using HTA125, TLR4 protein expression has been detected in monocytes, B cells and T cells in human peripheral blood. The human TLR4 gene has been mapped to chromosome 9q32. The immunogen used to generate the HTA125 hybridoma was human TLR4-transfected Ba/F3 cells. The HTA125 antibody reportedly blocks LPS-triggered, TLR4-mediated stimulation of cells. |
别名 | TLR4; CD284; Toll-like Receptor 4; ARMD10 |
同种亚型 | Mouse BALB/c IgG2a, κ |
反应种属 | Human (Tested in Development) |
性能供应商 | BD Pharmingen |
免疫原 | Human TLR4-transfected Ba/F3 cell line |
存放说明 | Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated with BD Horizon BV421 under optimal conditions that minimize unconjugated dye and antibody.
|
存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide. |
浓度 | 0.2 mg/ml |