Hu NKp80 PE 5D12 100Tst
货号：
566329-BD 基本售价：
8260.0 元 规格：
100TST
产品信息
概述| 货号 | 566329-BD |
| 描述 | The 5D12 monoclonal antibody specifically binds to NKp80 which is also known as C-type lectin domain family 5 member C (CLEC5C). NKp80 is a single-pass type II transmembrane glycoprotein that contains a C-type lectin extracellular domain and is expressed as a ~80 kDa disulfide-linked homodimer. NKp80 is encoded by KLRF1 (Killer cell lectin-like receptor subfamily F member 1) which maps to the NK-gene complex (NKC). NKp80 is expressed on most NK cells, and subsets of γδ T cells and effector-memory CD8 αβ T cells. NKp80 is not present in rodents. NKp80 is an activating coreceptor that induces NK cell-mediated cytotoxicity and proinflammatory cytokine (eg, IFN- γ and TNF) production upon interaction with its ligand, AICL (Activation induced C type lectin). AICL is encoded by CLEC2B that is selectively expressed on myeloid cells including activated monocytes, macrophages, and granulocytes. NKp80 can reportedly transduce signals through an atypical hemi-ITAM-like sequence motif and Syk kinase to trigger cellular responses. |
| 别名 | KLRF1; CLEC5C; C-type lectin domain family 5 member C; ML |
| 同种亚型 | Mouse IgG1, κ |
| 反应种属 | Human (QC Testing) |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human NKp80 extracellular domain |
| 存放说明 | Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.
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| 存储溶液 | Aqueous buffered solution containing BSA and ≤0.09% sodium azide. |
