Hu IRF8 PE U31-644 50ug
货号：
566373 基本售价：
8250.0 元 规格：
50ug
产品信息
概述| 货号 | 566373 |
| 描述 | The U31-644 monoclonal antibody specifically recognizes human Interferon regulatory factor 8 (IRF8) which is also known as Interferon consensus sequence-binding protein (ICSBP or H-ICSBP). IRF8 is a ~50 kDa transcription factor that belongs to the interferon (IFN) regulatory factor (IRF) family which consists of 9 members in both humans and mice. IRF8 is variably expressed in hematopoietic cells including monocytes, macrophages, dendritic cells, and B cells. IRF8 has a conserved N-terminal DNA-binding domain (DBD) and a divergent C-terminal region that functions as the regulatory domain which specifies interactions between IRF8 and other IRF family members, transcription factors, or cofactors. IRF8 functions as a transcriptional activator or repressor depending on the formation of heterodimeric DNA binding complexes with these different partners. IRF8 binds to specific DNA motifs including IFN-stimulated response elements (ISRE) and regulates expression of genes including those that encode IFN-alpha (IFN- α), IFN-beta (IFN-β) , and IFN-inducible MHC class I genes. IRF8 plays an important in the development of myeloid cells and B cells. It functions in innate and adaptive immunity by regulating the effector functions of monocytes/macrophages, B cells and dendritic cell subsets. IRF8 participates in the induction of Type I IFNs, TNF, IL-6, and IL-12 expression by leucocytes stimulated with ligands for Toll-like receptors and other pattern recognition receptors (PRRs). IRF8 is also involved in cell cycle regulations and apoptosis and may play a role in tumorigenesis. |
| 别名 | IRF-8; IRF8; ICSBP; H-ICSBP; ICSBP1 |
| 同种亚型 | Mouse IgG1, κ |
| 反应种属 | Human (QC Testing) |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human IRF8 Recombinant Protein |
| 存放说明 | Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.
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| 存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide. |
| 浓度 | 0.2 mg/ml |
