Hu IL-31RA Alexa 647 V1-1110 50ug
货号：
566351 基本售价：
7990.0 元 规格：
50ug
产品信息
概述| 货号 | 566351 |
| 描述 | The V1-1110 monoclonal antibody specifically recognizes the Interleukin-31 Receptor subunit alpha (IL-31R alpha, IL-31RA, or IL-31R α ) which is also known as gp130-like Monocyte Receptor (GLMR or hGLM-R) or Cytokine receptor-like 3 (CRL3). IL-31RA is a type I transmembrane glycoprotein that is encoded by IL31RA and is classified as a type I cytokine receptor. IL-31RA associates with the Oncostatin M Receptor (OSMR) to form a heterodimeric signaling receptor for IL-31. Through this heterodimeric receptor, IL-31 can elicit intracellular JAK/STAT (including activated Stat3, Stat5, or Stat1), RAS/ERK and PI3K/AKT signal transduction pathways. IL-31RA is variably expressed by monocytes, dendritic cells, keratinocytes, and epithelial cells. IL-31RA and OSMR are inducibly expressed by cells within the myelomonocytic lineage such as monocytes treated with IFN- γ and bacterial lipopolysaccharide (LPS). IL-31RA signaling plays important roles in both innate and adaptive immunity and inflammation in tissues that are in close contact with the environment including the skin, lung, and intestines. |
| 别名 | IL31RA; IL-31R-alpha; GLMR; GLM-R; hGLM-R; CRL3 |
| 同种亚型 | Rat IgG2a, κ |
| 反应种属 | Human (QC Testing) |
性能| 供应商 | BD Pharmingen |
| 存放说明 | Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated to Alexa Fluor® 647 under optimum conditions, and unreacted Alexa Fluor® 647 was removed.
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| 存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide. |
| 浓度 | 0.2 mg/ml |
