Hu ILT7 (CD85G) APC 17G10.2 100Tst
货号:
562355 基本售价:
7700.0 元 规格:
100Tst
产品信息
概述货号 | 562355 |
描述 | The 17G10.2 monoclonal antibody specifically binds to human Immunoglobulin Like Transcript 7 (ILT7), also known as CD85g. The ILT7 protein is encoded by the LILRA4 (Leukocyte Immunoglobulin Like Receptor subfamily A member 4) gene. ILT7 is a member of immunoglobulin-like transcripts (ILT) or leukocyte immunoglobulin-like receptor (LIR) gene family. ILT7 is selectively expressed on plasmacytoid dendrtic cells (pDC) but not on myeloid dendritic cells or other peripheral blood leukocytes. In response to IL-3, IL-3 receptor complex signaling downregulates ILT7 expression by pDC. ILT7 associates with the FcεRIγ signal adapter protein to form a receptor complex that can signal through activation of an immunoreceptor-based tyrosine activation motif (ITAM)-mediated signaling pathway. Signaling through the ILT7-FcεRIγ receptor complex negatively regulates the innate immune functions of pDC. ILT7 crosslinking inhibits TLR responses by pDC such as the stimulated production of type I interferon and other cytokines. Bone marrow stromal cell antigen 2 (BST2) has been identified as a biological ligand for ILT7. |
别名 | LILRA4; CD85g; ILT7; ILT-7; Immunoglobulin-like transcript 7 |
同种亚型 | Mouse IgG1, κ |
反应种属 | Human (QC Testing) |
性能供应商 | BD Pharmingen |
免疫原 | ILT7–FcεRIγ-transfected 2B4 cells |
标记 | APC |
存放说明 | Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated to APC under optimum conditions, and unconjugated antibody and free APC were removed.
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存储溶液 | Aqueous buffered solution containing BSA and ≤0.09% sodium azide. |