HuR PE 3A2 25ug
货号：
566341 基本售价：
7425.0 元 规格：
25UG
产品信息
概述| 货号 | 566341 |
| 描述 | The 3A2 monoclonal antibody specifically recognizes HuR (Human antigen R) which is encoded by ELAVL1 (ELAV like RNA binding protein 1). HuR belongs to the ELAVL (embryonic lethal, abnormal vision and Drosophila-like) family of proteins that includes HuB ( ELAVL2 ), HuC ( ELAVL3 ) and HuD ( ELAVL4 ). These proteins contain three RNA recognition motifs that selectively bind AU rich elements (AREs) found in the 3 untranslated regions of messenger RNAs. Although predominantly located in the nucleus, HuR shuttles between the nucleus and cytoplasm. HuR stabilizes ARE-containing mRNAs, regulates RNA splicing, and can thus influence the outcome of gene expression. HuR is expressed by a variety of cell types including leucocytes, eg, T cells, B cells, and dendritic cells, whereas the other ELAVL family members are primarily expressed by neurons. HuR is involved in regulating cellular growth and differentiation, eg, through the stabilization and shuttling of mRNAs including those encoding transcription factors, proto-oncogenes, costimulatory receptors, growth factors, cytokines, chemokines, and inflammatory mediators. Abnormal expression of HuR has been linked to a number of diseases, for example, overexpressed HuR levels have been detected in certain tumor cells. The 3A2 antibody crossreacts with mouse HuR as well as with human HuB and HuD, but not with HuC. |
| 别名 | HUR; ELAVL1; ELAV1; Hua; MelG |
| 同种亚型 | Mouse BALB/c IgG1, κ |
| 反应种属 | Mouse (QC Testing) Human (Tested in Development) |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human HuR Recombinant Protein |
| 存放说明 | Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.
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| 存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide. |
| 浓度 | 0.2 mg/ml |
