Hu CD85k (ILT3) Alexa 647 ZM3.8 100Tst
货号:
564182 基本售价:
7250.0 元 规格:
100Tst
产品信息
概述货号 | 564182 |
描述 | The ZM3.8 monoclonal antibody specifically binds to CD85k which is also known as Immunoglobulin-like transcript 3 (ILT-3) and Monocyte inhibitory receptor HM18. CD85k is encoded by LILRB4 (Leukocyte immunoglobulin-like receptor, subfamily B member 4) and is expressed as a type I transmembrane glycoprotein. CD85k is comprised of two C2-type Ig domains, a transmembrane region, and a cytoplasmic tail with three immunoreceptor tyrosine-based inhibitory motifs (ITIMs). CD85k is selectively expressed by myeloid antigen presenting cells including monocytes, macrophages, and dendritic cells. CD85k functions as an inhibitory receptor. ILT3 can also function in antigen capture and presentation. It is efficiently internalized upon cross-linking, and delivers its ligand to an intracellular compartment where it is processed and ultimately presented by APCs to T cells. Thus, ILT3 is a novel inhibitory receptor that can negatively regulate activation of APCs and can be used by APCs for antigen uptake. ILT3 expression is upregulated on tolerogenic dendritic cells that can induce regulatory T cells. |
别名 | LILRB4; ILT-3; HM18; LIRB4; LILRB5; LIR-5 |
同种亚型 | Mouse BALB/c IgG1 |
反应种属 | Human (QC Testing) |
性能供应商 | BD Pharmingen |
免疫原 | Human ILT3 Recombinant Protein |
标记 | Alexa Fluor 647 |
存放说明 | Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated to Alexa Fluor® 647 under optimum conditions, and unreacted Alexa Fluor® 647 was removed.
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存储溶液 | Aqueous buffered solution containing BSA and ≤0.09% sodium azide. |