Hu JNK1 W/Cont Pure G151-333 150ug
货号：
551197 基本售价：
6300.0 元 规格：
150ug
产品信息
概述| 货号 | 551197 |
| 描述 | C-Jun NH2-terminal kinase (JNK1) binds to the c-Jun terminal transactivation domain and phosphorylates it on Ser-63 and Ser-73. Phosphorylation enhances the transcriptional activity of c-Jun. The Ser-Pro-acidic sequence targeted by JNK1 kinase activity establishes it as a proline-directed kinase related to the MAP kinases and cyclin dependent kinases. JNK1 migrates with an apparent molecular weight of 46 kDa by SDS-PAGE. A related protein of 55 kDa has similar kinase activity. JNK1 may act as a tumor promoter in response to UV-irradiation since its activity is potently stimulated by such radiation. This has relevance to the observations that c-Jun transcriptional activity is upregulated by UV irradiation. The G151-333 antibody recognizes both the 46 kDa JNK1 and a related ~55 kDa protein (which may be a modified form of JNK1). It does not cross-react with JNK2. G151-333 precipitates an active kinase. A bacterially expressed fusion protein of human JNK1 was used as immunogen. |
| 同种亚型 | IgG1 |
| 反应种属 | Human (QC Testing) |
| 来源宿主 | Mouse |
| 使用方法 | WB |
性能| 供应商 | BD Pharmingen |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at -20°C.
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