Hu HLA-ABC PE EMR8-5 50Tst
货号:
565291 基本售价:
6270.0 元 规格:
50Tst
产品信息
概述货号 | 565291 |
描述 | The EMR8-5 monoclonal antibody recognizes a conserved epitope expressed on denatured human Major Histocompatibility Complex (MHC) Class I antigen heavy chain proteins, also known as, HLA (Human Leucocyte Antigens): HLA-A, HLA-B, and HLA-C (HLA-ABC). MHC Class I molecules are heterodimers that consist of a ~40-45 kDa transmembrane alpha chain subunit that is highly polymorphic and noncovalently associated with invariant β 2-microglobulin. MHC Class I antigens are normally expressed on most all nucleated cells. They can be highly expressed on certain activated cells or cells treated with a variety of agents including cytokines or inflammatory mediators. In contrast, they may be very lowly expressed on certain virus-infected or tumor cells. HLA class I antigens expressed by thymic epithelial cells are involved in the positive and negative selection of CD8+ T cells and their TCR repertoire during T cell maturation within the thymus. In the periphery, these HLA antigens serve to present antigens for the generation of effector and memory CD8+ T cell responses. MHC Class I recognition by certain NK receptors can protect target cells from NK cell-mediated lysis. The EMR8-5 antibody is useful for staining HLA Class I molecules found in formalin-fixed cells or paraffin-embedded tissue sections. |
别名 | HLA-A, HLA-B, HLA-C; HLAA, HLAB, HLAC; HLA-A,B,C |
同种亚型 | Mouse BALB/c IgG1, κ |
反应种属 | Human (QC Testing) |
性能供应商 | BD Pharmingen |
免疫原 | Human HLA-A Recombinant Protein |
标记 | PE |
存放说明 | The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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存储溶液 | Aqueous buffered solution containing BSA and ≤0.09% sodium azide. |