Hu CD172a/b BV421 SE5A5 50Tst
货号：
565036 基本售价：
5830.0 元 规格：
50Tst
产品信息
概述| 货号 | 565036 |
| 描述 | The SE5A5 monoclonal antibody specifically binds to a common epitope on CD172a/ SIRPα (90 kDa) and CD172b/SIRPβ1 (50 kDa) . These transmembrane glycoproteins are members of the Signal Regulatory Protein (SIRP) family that, in turn, belongs to the Immunoglobulin superfamily. The SIRP family is comprised of two subgroups, SIRPα and SIRPβ that are distinguished by the presence (α) or absence (β) of a cytoplasmic domain containing two immunoreceptor tyrosine-based inhibition motifs (ITIM). CD172a/ SIRPα is expressed on CD34+ stem/progenitor cells, cardiomyocytes, monocytes, macrophages, granulocytes, dendritic cells, and in the central nervous system. It binds to CD47 and is implicated in mediating inhibitory signals via the ITIM/SHP-2 association. CD172b/ SIRPβ1 does not possess a cytoplasmic domain but instead the transmembrane domain contains a positively-charged residue that can interact with another transmembrane protein, DAP-12/KARAP. DAP-12 has two immunoreceptor tyrosine-based activat ion motifs (ITAM) within its cytoplasmic domain that are thought to link CD172bto cellular activation signaling .CD172b is expressed on myeloid cells, including peripheral blood monocytes and granulocytes. It is not expressed on CD34+ cells. CD172aandCD172b have complementary role s in signal regulation and may work together in tuning certain cellular responses to stimuli. |
| 别名 | SIRP alpha/beta1; SIRPα/SIRPβ1; Signal Regulatory Protein α/β1 |
| 同种亚型 | Mouse BALB/c IgG1, κ |
| 反应种属 | Human (QC Testing) |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human SIRP alpha extracellular domain Recombinant Protein |
| 标记 | BV421 |
| 存放说明 | Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated with BD Horizon™ BV421 under optimum conditions, and unconjugated antibody and free BD Horizon™ BV421 were removed.
|
| 存储溶液 | Aqueous buffered solution containing BSA and ≤0.09% sodium azide. |
