Ms/Hu IKK Gma Pure C73-764 100ug
货号：
559675 基本售价：
5560.0 元 规格：
100ug
产品信息
概述| 货号 | 559675 |
| 描述 | The transcription factor NF- κ B, ( nuclearfactorkappa-B ) is controlled by interaction with an inhibitory subunit, I κ B, which restricts NF- κ B to the cytoplasm. Following stimulation by various cytokines or other stimuli, I κ B becomes degraded and NF- κ B is released to the nucleus. The release of I κ B from NF- κ B is a critical step in the activation of NF- κ B signal pathways. A group of proteins form an NF- κ B regulatory complex, or signalsome. Two members of this complex are a pair of closely related serine/threonine kinases, IKK α and IKK β (aka IKK-1 and IKK-2), which phosphorylate critical residues of I κ B, thus targeting it for subsequent degradation. The IKK complex contains similar amounts of IKK α , IKK β , as well as two other polypeptides, which are differentially processed forms of a third subunit, IKK γ . IKK α and IKK β become activated following phosphorylation by upstream kinases, including NF- κ B-inducing kinase (NIK) and MEKK1. IKK γ interacts preferentially with IKK β and is required for the activation of the IKK complex. Thus the IKK kinases play an important role in the activation of NF- κ B. IKK γ migrates as a doublet between 50-55 kDa in SDS-PAGE. |
| 别名 | NEMO |
| 同种亚型 | IgG1 |
| 反应种属 | Mouse (QC Testing) Human (Tested in Development) |
| 来源宿主 | Mouse |
| 使用方法 | WB, IP |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Recombinant Human IKKγ |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at 4°C.
|
| 存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide. |
| 浓度 | 0.5 mg/ml |
