Hu CD158f BV421 UP-R1 50Tst
货号：
566330 基本售价：
5500.0 元 规格：
50Tst
产品信息
概述| 货号 | 566330 |
| 描述 | The UP-R1 monoclonal antibody specifically recognizes CD158f which is also known as KIR2DL5. CD158f is a ~60 kDa single-pass type I transmembrane glycoprotein that belongs to the KIR (Killer cell Ig-like receptors) family within the Ig gene superfamily. CD158f is encoded by two gene paralogs, KIR2DL5AandKIR2DL5B that show greater than 99% identity in their coding sequences. CD158f molecules contain two extracellular C2-type Ig-like domains and a long cytoplasmic domain containing one canonical immunoreceptor tyrosine-based inhibitory motif (ITIM) and another atypical ITIM sequence. Although the exact ligands for CD158f have not yet been identified, the inhibitory function of UP-R1 antibody-crosslinked CD158f was shown to primarily depend upon a Src homology region 2-containing protein tyrosine phosphatase-2 (SHP-2) -dependent pathway. CD158f is highly polymorphic and is expressed on subsets of NK cells and T lymphocytes by some individuals. UP-R1 recognizes cell surface CD158f encoded by the most commonly expressed allele, KIR2DL5A*001 . The UP-R1 antibody has been predicted to recognize CD158f molecules encoded by other transcriptionally-active KIR2DL5alleles,A*012andB*00602. |
| 别名 | CD158F; CD158F1; CD158F2; KI2LA; KIR2DL5; KIR2DL5A; KIR2DL5B |
| 同种亚型 | Mouse BALB/c IgG1 |
| 反应种属 | Human (QC Testing) |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human CD158f Recombinant Protein |
| 存放说明 | Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated with BD Horizon™ BV421 under optimum conditions, and unconjugated antibody and free BD Horizon™ BV421 were removed.
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| 存储溶液 | Aqueous buffered solution containing BSA and ≤0.09% sodium azide. |
