Hu TLR9 PE eB72-1665 100Tst
货号：
560425 基本售价：
5310.0 元 规格：
100Tst
产品信息
概述| 货号 | 560425 |
| 描述 | Toll-like receptor 9 (TLR9), also designated as CD289, is a type 1 transmembrane glycoprotein (~110-119 kDa calculated molecular weights for protein isoforms) encoded by the TLR9 gene in chromosome 3. TLR9 is a member of the Toll-like receptor (TLR) family whose members play fundamental roles in pathogen recognition and activation of innate immunity. TLR9 is highly expressed by plasmacytoid dendritic cells and B cells and at lower levels in some other cell types. TLR9 is expressed predominantly in the endoplasmic reticulum. It is recruited to endosomal and lysosomal compartments upon cellular stimulation by bacterial, viral or synthetic DNA molecules that contain unmethylated CpG dinucleotide sequences. TLR9 generated signals lead to the activation of genes that express type-I interferons and proinflammatory cytokines including IL-6 and IL-12. TLR9-mediated signaling is also implicated in acquired immune responses as well as in the pathogenesis of autoimmune diseases. The eB72-1665.1 mAb recognizes the human TLR9 epitope from the peptide sequence, amino acids 273-288. |
| 别名 | CD289, toll-like receptor 9 |
| 同种亚型 | IgG2a,κ |
| 反应种属 | Human (QC Testing) |
| 来源宿主 | Rat |
性能| 供应商 | BD Pharmingen |
| 标记 | PE |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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| 存储溶液 | Aqueous buffered solution containing BSA and ≤0.09% sodium azide. |
