Hu JNKK Pure G282-114 100ug
货号：
554105 基本售价：
5282.0 元 规格：
100ug
产品信息
概述| 货号 | 554105 |
| 描述 | JNKK (JNK kinase) is a member of the mitogen-activated protein kinase (MAPK) kinase family. MAPKK family members are components of key signaltransduction cascades that link events at the cell surface to responses in the nucleus. MAPK signaling cascades are found in species as varied as yeast and humans with many of the proteins being well conserved. Members of the MAPK family are activated by dual phosphorylation on threonine and tyrosine in response to a variety of extracellular stimuli. Activation of the JNK (Jun N- terminal kinase)/SAPK (stress-activated protein kinase) MAPK pathway occurs in response to factors that cause stress to the cell, and leads to Jun induced transcription. In this protein kinase cascade, MEKK (MAPK kinase kinase) phosphorylates JNKK, JNKK phosphorylates JNK, and JNK phosphorylates Jun. Phosphorylation increases the transcriptional activity of Jun. JNKK migrates at 45 kDa in SDS-PAGE. Clone G282-114 recognizes human JNKK. It may cross-react with other kinases in the MAP kinase pathway. |
| 同种亚型 | IgG1 |
| 反应种属 | Human (QC Testing) |
| 来源宿主 | Mouse |
| 使用方法 | WB, IP |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Recombinant Human JNKK |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at 4°C.
|
| 存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide. |
| 浓度 | 0.5 mg/ml |
