Hu Fc Mu Receptor Biotin HM14-1 50ug
货号：
563018 基本售价：
5115.0 元 规格：
50ug
产品信息
概述| 货号 | 563018 |
| 描述 | The HM14-1 monoclonal antibody specifically binds to the FAIM3 -encoded high affinity receptor for IgM (also known as, Fcµ Receptor, FcμR, Fc mu receptor, Immunoglobulin mu Fc receptor, FcmR, IgM Fc receptor). The FcμR is a type 1 transmembrane glycoprotei n that contains an extracellular Ig-like domain with sequence similarities to Fcα/μR and pIgR. It is likewise known as Fas apoptotic inhibitory molecule 3, TOSO or Regulator of Fas-induced apoptosis Toso based on its capacity to counter apoptosis mediated by Fas/CD95 (or TNF) in some experimental model systems. FcμRs are expressed by B cells, CD4 + T cells, CD8+ T cells, and NK cells and are highly expressed on Chronic Lymphocytic Leukemia cells. FcμRs may play roles in cellular activation, antigen presentation and IgM-dependent cell-mediated cytotoxicity. The relatively long cytoplasmic tail of FcμR contains several conserved tyrosine and serine residues. These get phosphorylated after FcμR ligation with Ig M immune complexes and may initiate signaling responses. Lymphocyte FcμRs can mediate the internalization of IgM-bound antigens including microbial and viral antigens. This in turn may cause cellular activation due to subsequent antigen processing and exposure of activating ligands to intracellular receptors including T oll-like receptors. The HM7-10 antibody, a related FcμR-specific antibody, reportedly recognizes an epitope near the IgM ligand binding site of the FcμR whereas the HM14-1 antibody does not. |
| 别名 | FcμR; FcmR; Fc mu receptor; IgM Fc receptor; FAIM3; TOSO |
| 同种亚型 | Mouse BALB/c IgG1, κ |
| 反应种属 | Human (QC Testing) |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human IgM Fc Receptor Transfected Cell Line |
| 标记 | Biotin |
| 存放说明 | Store undiluted at 4°C.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated with biotin under optimum conditions, and unreacted biotin was removed.
|
| 存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide. |
| 浓度 | 0.5 mg/ml |
