Hu Cyclin A1 Pure B88-2 100ug
货号：
556600 基本售价：
5092.0 元 规格：
100ug
产品信息
概述| 货号 | 556600 |
| 描述 | Cyclins and cyclin-dependent kinases (cdks) are evolutionarily conserved proteins that are essential for cell-cycle control in eukaryotes. Cyclins contain a conserved amino acid sequence motif, the cyclin box, which allows their binding to cdks to form active complexes that regulate the progression of the cell cycle. These complexes are regulated by activating and inhibitory phosphorylation events, as well as by interactions with small regulatory proteins including p21 and p27[Kip1]. Specific substrates for cyclin-cdk complexes include nuclear lamins, histones, tumor suppressor genes, nucleolin and others. Cyclin A plays a regulatory role during both S-phase and G2/M transitions through its association with cdk2 and cdk1, respectively. A related cyclin, designated cyclin A1, has also been identified. Cyclin A1 shares 48% sequence identity with cyclin A. Yeast two hybrid analysis has shown that, like cyclin A, cyclin A1 also forms a complex with cdk2. Cyclin A1 does not appear to bind cdk1, cdk2 or cdk5. In contrast to cyclin A, cyclin A1 appears to be predominantly expressed in myeloid leukemia cells; however mRNA analysis has suggested that low levels of gene expression may be found in many other hematopoietic and non-hematopoietic cell types. Human cyclin A1 is observed at ~ 65 kD by SDS-PAGE. B88-2 reacts with human cyclin A1. It does not cross-react with cyclin A. A polypeptide fragment containing amino acids 46-93 of human cyclin A1 was used as immunogen. |
| 同种亚型 | IgG1 |
| 反应种属 | Human (QC Testing) |
| 来源宿主 | Mouse |
| 使用方法 | WB |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human cyclin A1 aa. 46-93 |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at 4°C.
|
| 存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide. |
| 浓度 | 0.5 mg/ml |
