Hu TRAF3 Pure B1-6 100ug
货号：
556461 基本售价：
5092.0 元 规格：
100ug
产品信息
概述| 货号 | 556461 |
| 描述 | TRAF3 (TNF Receptor Associated Factor 3) is a member of a group of putative signal transducing molecules which interact with several members of the TNF receptor family. TRAF3 was discovered based on its interaction with CD40 and the dominant oncogene of Epstein-Barr virus, LMP-1. As such, it also known as CRAF1 and LAP1. TRAF proteins share a novel C-terminal homology region, the “TRAF” domain, as well as an N-terminal Zinc/RING finger and/or multiple Zinc finger motifs. A leucine zipper (coiled coil) region lies between the Zinc/RING finger and TRAF domains and may promote homodimerization and heterodimerization of TRAF proteins and receptor interaction. In vitro, TRAF3 binds directly to the cytoplasmic domains of CD30, CD40, LT- β R and TNFR type II. TRAF3 has been shown to play a role in intracellular signal pathways associated with these receptors, including induction of cell death and of the transcription factor, NF- κ B. Studies on TRAF3- deficient mice have shown that TRAF3 is required for postnatal development and for normal T-cell function. TRAF3 migrates at a molecular weight of ~64 kDa in SDS/PAGE. The B1-6 antibody recognizes an ~64 kDa band corresponding to human TRAF3. A recombinant human TRAF3 protein fragment corresponding to amino acids 571-620 was used as immunogen. |
| 同种亚型 | IgG1 |
| 反应种属 | Human (QC Testing) |
| 来源宿主 | Mouse |
| 使用方法 | WB |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Recombinant human TRAF3 protein |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at 4°C.
|
| 存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide. |
| 浓度 | 0.5 mg/ml |
