Hu Disial GD3 Pure MB3.6 100ug
货号：
554274 基本售价：
5092.0 元 规格：
100ug
产品信息
概述| 货号 | 554274 |
| 描述 | Gangliosides are sialic-acid bearing glycolipids expressed on the surface of all mammalian cells, and are likely involved in mediating cell-substratum interactions. They are important target antigens for antibody mediated cytolysis of human melanoma and neuroblastoma cells. Human melanoma cells produce gangliosides GD2 and/or GD3 which are present in substratum-attached material, and may play a significant role in the melanoma metastatic phenotype. Ganglioside GD3 is a major surface marker on most human melanoma cells. MB3.6 has been used to localize GD3 in the plasma membrane and in focal adhesion plaques of human melanoma cells. Clone MB3.6 has also been shown to lyse GD3 positive human melanoma cells by both antibodydependent and complement-mediated cytotoxicity, and to inhibit the growth of human melanoma cells in athymic nude mice. Clone MB3.6 specifically reacts with human GD3 ganglioside. It does not cross-react with a variety of other gangliosides purified from melanoma or neuroblastoma cells. The FM9 human melanoma cell line was used as the immunogen. |
| 同种亚型 | IgG3,κ |
| 反应种属 | Human (QC Testing) |
| 来源宿主 | Mouse |
| 使用方法 | FC, Cyt, IHC(Fr), IF |
性能| 供应商 | BD Pharmingen |
| 免疫原 | FM9 human melamona cell line |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at 4°C.
|
| 存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide. |
| 浓度 | 0.5 mg/ml |
