Hu Rb (aa 444-535) Pure XZ91 100ug
货号：
554145 基本售价：
5092.0 元 规格：
100ug
产品信息
概述| 货号 | 554145 |
| 描述 | The retinoblastoma gene encodes a nuclear phosphoprotein (Rb or p110Rb) which is expressed in most normal cells of vertebrates and acts as a tumor suppressor gene product. An underphosphorylated form of Rb is mainly found in resting or fully differentiated cells, whereas the hyperphosphorylated form is present in proliferating cells. Only the underphosphorylated form of Rb binds specifically to viral oncogenes such as SV40 large T, adenoviral E1A and HPV-E7. This interaction may partially contribute to the transforming activity of these viral oncoproteins. Rb also interacts with several cyclins including A, D and E, as well as the transcriptional activator E2F. The importance of these interactions for the biological function of Rb is still being elucidated. Clone XZ91 recognizes an epitope located between amino acids 444-535 of human Rb. XZ91 cross reacts with chicken and mink Rb. A recombinant carboxy-terminal truncated Rb protein (containing approximately 60 kD of the Rb coding region) was used as immunogen. |
| 别名 | RB |
| 同种亚型 | IgG2a |
| 反应种属 | Human (QC Testing) Chicken, Mink (Reported) |
| 来源宿主 | Mouse |
| 使用方法 | WB, IP, IF |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Recombinant carboxy-terminal truncated Rb protein |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at 4°C.
|
| 存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide. |
| 浓度 | 0.5 mg/ml |
