Hu Rb (aa 443-622) Pure XZ55 100ug
货号：
554144 基本售价：
5092.0 元 规格：
100ug
产品信息
概述| 货号 | 554144 |
| 描述 | The retinoblastoma gene encodes a nuclear phosphoprotein (Rb or p110[Rb]) which is expressed in most normal cells of vertebrates and acts as a tumor suppressor gene product. An underphosphorylated form of RB is mainly found in resting or fully differentiated cells, whereas the hyperphosphorylated form is present in proliferating cells. Only the underphosphorylated form of RB binds specifically to viral oncogenes such as SV40 large T, adenviral EIA and HPV-E7. This interaction may partially contribute to the transforming activity of these viral oncoproteins. Rb also interacts with several cyclins including A, D, and E as well as the transcriptional activator E2F. The importance of these interactions for the biological function of Rb is still being elucidated. XZ55 recognizes an epitope located between amino acids 443-622 of human Rb. It cross-reacts with chicken, mouse and Xenopus Rb, and a putative quail Rb.A recombinant carboxy-terminal (amino acids 387-928) human Rb protein was used as immunogen. |
| 别名 | RB |
| 同种亚型 | IgG1 |
| 反应种属 | Human (QC Testing) Mouse, Chicken, Xenopus, Quail (Reported) |
| 来源宿主 | Mouse |
| 使用方法 | WB, IP |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Recombinant carboxy-terminal human RB protein aa. 387-928 |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at 4°C.
|
| 存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide. |
| 浓度 | 0.5 mg/ml |
