Hu Rb (aa 300-380) Pure G3-349 100ug
货号：
554140 基本售价：
5092.0 元 规格：
100ug
产品信息
概述| 货号 | 554140 |
| 描述 | Members of the retinoblastoma (Rb) family, including the related proteins p107 and p130, share several properties, including the ability to regulate E2F-dependent transcription and to regulate cell-cycle progression. The Rb gene product is a phosphoprotein that is expressed in most normal cells of vertebrates. Rb acts as a tumor suppressor by providing a cell cycle checkpoint between the G1 and S phases. The active, underphosphorylated form of Rb (Rb or pRb) is primarily found in resting or fully differentiated cells. The activity of Rb is negatively regulated by cyclin-dependent kinases, which phosphorylate Rb in late G1. Thus, the hyperphosphorylated form (ppRb) is primarily found in proliferating cells. pRb inactivation is a critical step leading to S-phase commitment at the G1 checkpoint of the cell cycle. In addition, the underphosphorylated form of Rb may bind to viral oncogenes such as SV40 large T Ag, adenoviral E1A and HPVE7, which may contribute to the transforming activity of these viral oncoproteins. The G3-349 antibody recognizes an epitope located between amino acids 300-380 of human Rb. A truncated Rb fusion protein was used as immunogen. |
| 同种亚型 | IgG1 |
| 反应种属 | Human (QC Testing) |
| 来源宿主 | Mouse |
| 使用方法 | WB, IP |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Rb fusion protein |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at 4°C.
|
| 存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide. |
| 浓度 | 0.5 mg/ml |
