Hu CD119 PE GIR-208 200ug
货号：
558934 基本售价：
4410.0 元 规格：
200ug
产品信息
概述| 货号 | 558934 |
| 描述 | The GIR-208 antibody recognizes the extracellular region of CD119 which is also known as the alpha chain subunit (80-95 kDa glycoprotein) of the human interferon- γ receptor (IFN- γRα ). The functionally active-form of the human IFN- γ receptor consists of two (or more) subunits, with IFN- γRα responsible for IFN- γ binding and both the IFN- γRαandβ chains required for the transduction of biologic responses. The IFN- γreceptorα chain (CD119) is expressed on the surface of most human cells (except mature erythrocytes) including monocytes, macrophages, T cells, B cells, NK cells, neutrophils, fibroblasts, epithelial cells, and endothelium. Binding of 125I-labeled GIR-208 antibody to IFN- γRα + cells is reported to be specifically inhibited in the presence of excess IFN- γ . GIR-208 does not cross react with IFN- γ as tested by ELISA. The ability of this antibody to bind to IFN- γ receptors of species other than human has not been determined. The immunogen used to generate this hybridoma was human IFN- γRα purified from human placenta. The GIR- 208 has been reported to block the binding of 125I-human IFN- γ to IFN- γRα + cells as well as purified, soluble human IFN- γRα . GIR-208 is a neutralizing antibody that has been shown to neutralize the anti-viral activity of IFN- γ on WISH cells in a dose-dependent fashion. |
| 别名 | IFN-γ Receptor α chain, IFNγRα |
| 同种亚型 | IgG1,κ |
| 反应种属 | Human (QC Testing) |
| 来源宿主 | Mouse |
| 使用方法 | FC |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human IFN-γRα |
| 标记 | PE |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
|
| 存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide. |
| 浓度 | 0.2 mg/ml |
