Hu Cyclin C Serum Poly 0.1mL
货号：
558903 基本售价：
4218.0 元 规格：
0.1mL
产品信息
概述| 货号 | 558903 |
| 描述 | Cyclins and cyclin-dependent kinases (cdks) are evolutionarily conserved proteins that are essential for cell-cycle control in eukaryotes. Cyclins contain a conserved amino acid sequence motif, the cyclin box, which allows their binding to cdks to form active complexes that regulate progression of the cell cycle. More recently, cyclins are being shown to have additional functions not restricted to cell cycle regulation. Thus, cyclins have been placed into functional groups as follows: Group 1 cyclins (A, B, D1, D2, D3, E and F) function primarily in cell cycle reguation; Group 2 cyclins (C and H) also play a role in transcriptional regulation; Group 3 cyclins (G1, G2 and I) may play a role distinct from either cell cycle or transcriptional regulation. Cyclin C has been identified in both human and chicken species. Like many cyclins, the expression of cyclin C oscillates throughout the cell cycle, with a peak observed during G1 phase. Cyclin C may play a dual role within the cell in its ability to regulate both cell cycle progression as well as gene transcription. Cyclin C associates with Cdk8, forming a complex which can induce gene transcription of Cdc2 (Cdk1). Because Cdc2 kinase is important for cell entry into mitosis, cyclin C’s ability to regulate cell cycle progression may be attributed, in part, to modulation of Cdc2 protein expression.6 Cyclin C has a predicted molecular weight of 36 kD. The polyclonal antiserum reacts with human and mouse cyclin C. A polypeptide fragment containing amino acids 290-303 (QGPNGSQNSSYSQS) at the C-terminus of human cyclin C, with the addition of a C-terminal cysteine (C) residue to facilitate conjugation to KLH, was used as immunogen. |
| 反应种属 | Mouse (QC Testing) Human (Tested in Development) |
| 来源宿主 | Rabbit |
| 使用方法 | WB, IP |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human Cyclin C polypeptide fragment aa. 290-303 |
| 存放说明 | The polyclonal antibody was purified from antiserum by negative adsorption and affinity chromatography.Store undiluted at 4°C.
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| 存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide. |
