Hu A20 Pure E5-1619 50ug
货号：
550859 基本售价：
3933.0 元 规格：
50ug
产品信息
概述| 货号 | 550859 |
| 描述 | A20 was originally identified as a zinc finger protein, containing multiple Cys2/Cys2 finger motifs, induced by tumor necrosis factor alpha (TNFα). Further research has shown that A20 can negatively regulate NF-κB gene expression. NF-κB is an ubiquitously expressed transcription factor that regulates many genes involved in activation of inflammatory and cytokine responses. TNFα induces the activation of NF-κB by first recruiting a number of proteins to the TNF receptor. RIP and TRADD are two effector proteins which bind to the intracellular portion of the TNF receptor and form a multiprotein complex. Additional proteins, such as TRAF2 can interact with members of this complex. Although the exact mechanism of A20 regulation is unknown, it is believed that A20 interferes with either a TNF-induced RIP or TRAF2 mediated signaling pathway to block NF-κB expression. A20 mRNA is highly expressed in lymphoid tissues. A20 migrates in SDS/PAGE at ~80 kDa, which is equivalent to the predicted molecular weight. The antibody recognizes human A20. A fusion protein corresponding to the full length of human A20 was used as the immunogen. |
| 同种亚型 | Mouse IgG1, λ |
| 反应种属 | Human (QC Testing) |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human A20 |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at 4°C.
|
| 存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide. |
| 浓度 | 0.5 mg/ml |
