Hu IKKAlp Pure B78-1 100ug
货号：
556532 基本售价：
3892.0 元 规格：
100ug
产品信息
概述| 货号 | 556532 |
| 描述 | The nuclear transcription factor kappa-B, NF- κ B, is controlled by interaction with an inhibitory subunit, I- κ B, which restricts NF- κ B to the cytoplasm. Following stimulation by various cytokines or other stimuli, I- κ B becomes degraded and NF- κ B is released to the nucleus. The release of I- κ B from NF- κ B is thought to be a critical point in the activation of NF- κ B signal pathways. A group of proteins form an NF- κ B regulatory complex, or signalsome. Two members of this complex are a pair of closely related kinases, IKK α and IKK β (also called IKK-1 and IKK-2). IKK α and IKK β are serine/threonine kinases which share approximately 50% sequence identity. In addition to their kinase domains, these proteins each contain leucine zipper and helix-loop-helix regions which facilitate their interaction with each other as well as interaction(s) with other proteins within the IKK complex. Both IKK α and IKK β phosphorylate critical residues of I- κ B, thus targeting it for subsequent degradation. IKK α and IKK β become activated themselves following phosphorylation by upstream kinases, including NF- κ B-inducing kinase (NIK) and MEKK1. Thus the IKK kinases play an important role in the activation of NF- κ B. IKK α migrates at a molecular weight of 85 kD in SDS-PAGE. Clone B78-1 recognizes human IKK α . It does not cross-react with IKK β . Full length, recombinant human IKK α was used as immunogen. The reactivity of B78-1 was verified by immunoprecipitation and western blot analysis. |
| 同种亚型 | IgG2b |
| 来源宿主 | Mouse |
| 使用方法 | WB, IP |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human IKKα |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at 4°C.
|
| 存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide. |
| 浓度 | 0.5 mg/ml |
