Hu CD3Epsilon FITC APA1/1 100Tst
货号：
558261 基本售价：
3840.0 元 规格：
100Tst
产品信息
概述| 货号 | 558261 |
| 描述 | Monoclonal antibody APA1/1 reacts with the intracellular domain of the epsilon chain of the CD3 molecule (CD3- ε ). This antibody does not react with the extracellular region of CD3- ε . The assembly of the T cell antigen receptor (TCR)-CD3 complex has been suggested to take place by pairwise interactions of the CD3- ε subunit with either CD3- γ or CD3- δ . These dimers then associate with the TCR heterodimer a/ βorγ/δ , and the CD3- ζ homodimer to form the full complex. Studies show that antibodies APA1/1 and SP34 gave a strong reaction with COS cells singly transfected with CD3- ε . Other anti-CD3 antibodies (OKT3, WT31, UCHT1, Leu4) did not react with COS cells singly transfected with CD3- ε . This reagent could be useful for the study of T cell development or the study of conformational changes of CD3- ε upon ligand binding to TCR-CD3 complex. |
| 同种亚型 | IgG1,κ |
| 反应种属 | Human (QC Testing) |
| 来源宿主 | Mouse |
| 使用方法 | IC/FC |
性能| 供应商 | BD Pharmingen |
| 标记 | FITC |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated with FITC under optimum conditions, and unreacted FITC was removed.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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| 存储溶液 | Aqueous buffered solution containing BSA and ≤0.09% sodium azide. |
