Hu CD140b Pure 28 50ug
货号：
610113 基本售价：
3726.0 元 规格：
50ug
产品信息
概述| 货号 | 610113 |
| 描述 | Platelet-derived growth factor (PDGF) is a potent mitogen for cells of esenchymal origin and exerts its effects by binding to the PDGF receptor (PDGFR), a transmembrane protein tyrosine kinase. Both PDGF and PDGFR consist of subunits that form homo- or heterodimers with varying specificities: PDGF-AA binds only to αα PDGFR, PDGF-AB binds to both ααandαβ PDGFR, and PDGF-BB binds to all three PDGFRs. Ligand binding induces phosphorylation and activation of the receptor and, in turn, initiation of an intracellular phosphorylation cascade. PDGFR localizes primarily to membrane invaginations termed caveolae, compartments that are enriched in several of its downstream effectors, including PI3 kinase, Shc, NCK, and PTP1D. Additionally, the β subunit of PDGFR has been implicated in cellular transformation. This effect is mediated by a C-terminal region of PDGFR β and depends on pathways that involve either PLC β or PI3 kinase. |
| 别名 | PDGF Receptor β |
| 同种亚型 | IgG2b |
| 反应种属 | Human (QC Testing) |
| 来源宿主 | Mouse |
| 使用方法 | WB, IHC, IF |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human PDGF Receptor β aa. 1-187 |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at -20°C.
|
| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
