Hu IKK Gma (pS376) PE N19-39 50Tst
货号：
562590 基本售价：
3675.0 元 规格：
50Tst
产品信息
概述| 货号 | 562590 |
| 描述 | The N19-39 monoclonal antibody specifically binds to the IKK-gamma protein phosphorylated at the Ser376 site, ie, IKKγ (pS376). IKKγ is also known an NEMO (NF-kappa-B essential modifier) and is encoded by the IKBKG (inhibitor of kappa light polypeptide ge ne enhancer in B-cells, kinase gamma) gene. The nuclear transcription factor kappa-B, NF-κB, is controlled by interaction with an inhibitory subunit, IκB, which restricts NF-κB to the cytoplasm. Following stimulation by various cytokines or other stimu li, IκB becomes degraded and NF-κB is released to the nucleus. The release of IκB from NF-κB is thought to be a critical point in the activation of NF-κB signal pathways. Activated NF-κB regulates genes involved in various pathways including inflammation, immunity, and cell survival signaling pathways. A group of proteins form an NF-κB regulatory complex, or signalsome. Two members of this complex are a pair of closely related serine/threonine kinases, IKKα and IKKβ (also called IKK-1 and IKK-2), wh ich phosphorylate critical residues of IκB, thus targeting it for subsequent degradation. The IKK complex contains similar amounts of IKKα, IKKβ as well as two other polypeptides, which are differentially processed forms of a third subunit, IKKγ. IKKα and IKKβ become activated following phosphorylation by upstream kinases, including NF-κB-inducing kinase (NIK)4 and MEKK1. IKKβ has been shown to phosphorylate IKKγ at serine 376 in response to signaling through the TNF receptor or the Tax oncoprotein of human T-cell leukemia virus type 1. IKKγ has an essential regulatory role in the IKK complex and is required for the activation of the NF-κB pathway in response to multiple cellular stimuli. IKKγ isoforms migrate as a doublet of ~50-55 kDa upon Western blot analysis. |
| 别名 | IKBKG; IKKγ; IKKG; IKK-gamma; AMCBX1; FIP3; IKKAP1; IP1; IP2; IPD2; NEMO |
| 同种亚型 | Mouse IgG1, κ |
| 反应种属 | Human (QC Testing) |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Phosphorylated Human IKKγ Peptide |
| 标记 | PE |
| 存放说明 | Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.
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| 存储溶液 | Aqueous buffered solution containing BSA and ≤0.09% sodium azide. |
