Hu Fli-1 Pure G146-254 100ug
货号：
554267 基本售价：
3614.0 元 规格：
100ug
产品信息
概述| 货号 | 554267 |
| 描述 | Fli-1 is a 50 kDa ets-related transcription factor. Like other ets-related proteins it binds to consensus sites in DNA through a 85 amino acid ets domain in the carboxyl region of the protein. Fli-1 is associated with Ewing sarcoma through at (11;22)(q24;q12) chromosomal translocation. This translocation brings the 5 region of the EWS gene into conjunction with the 3 region of the Fli-1 gene encoding the ets-DNA binding domain. Such a translocation is found in 85% of Ewing sarcomas. The resulting fusion protein has the DNA binding activity of Fli-1 and, with the EWS domain, it is also a more potent transcriptional activator than Fli-1 itself. The strong transforming activity of the EWS-Fli-1 fusion protein may in part be due to its ability to trans-activate the promoter for c-myc. C-myc is known to be elevated in Ewing sarcomas. Clone G146-254 was raised against a bacterially expressed Fli-1 ets domain fusion protein. |
| 同种亚型 | IgG2a |
| 反应种属 | Human (QC Testing) |
| 来源宿主 | Mouse |
| 使用方法 | WB, GS, IP |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Fli-1 ets Domain Fusion Protein |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at 4°C.
|
| 存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide. |
| 浓度 | 0.5 mg/ml |
