Hu/NHP CD8 Horizon V500 SK1 50Tst
货号：
561618 基本售价：
3600.0 元 规格：
50Tst
产品信息
概述| 货号 | 561618 |
| 描述 | The SK1 monoclonal antibody specifically binds to CD8 alpha (CD8α). CD8α is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily. CD8α is expressed by the majority of thymocytes, by subpopulations ofαβ T cells and γδ T cells and by some NK cells. Cell surface CD8α is expressed either as a disulfide-linked homodimer (CD8αα) or as a heterodimer (CD8αβ) when disulfide-bonded to a CD8 beta chain (CD8β). CD8-positive αβ T cells coexpress both CD8αα homodimers and CD8αβ heterodimers whereas some γδ T cells and NK cells express CD8αα homodimers. CD8 plays important roles in T cell activation and selection. The extracellular IgSF domain of CD8α binds to a non-polymorphic determinant on HLA class I molecules (α3 domain) and enables CD8 to function as a co-receptor with MHC class I-restricted TCR during T cell recognition of antigen. The cytoplasmic domain of CD8α associates with Lck, a Src family protein tyrosine kinase that is involved in intracellular signaling. |
| 别名 | CD8α; CD8A; CD8 alpha; Leu2a; MAL; T8; p32 |
| 同种亚型 | Mouse BALB/c IgG1, κ |
| 反应种属 | Rhesus, Cynomolgus, Baboon (QC Testing) Human (Tested in Development) |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human Peripheral Blood T Cells |
| 标记 | V5 |
| 存放说明 | Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated with BD Horizon™ V500 under optimum conditions, and unreacted BD Horizon™ V500 was removed.
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| 存储溶液 | Aqueous buffered solution containing protein stabilizer, glycerol and ≤0.09% sodium azide. |
