Hu CD91 PE A2MR-A2 100Tst
货号：
550497 基本售价：
3575.0 元 规格：
100Tst
产品信息
概述| 货号 | 550497 |
| 描述 | Reacts with a 600 kDa, type I membrane single protein, also known as the α 2 Macroglobulin ( α 2M) receptor/low density lipoprotein receptor-related protein 1 (LRP-1). Reported to be an endocytic receptor involved with intracellular signalling, lipid homeostasis, clearance of apoptotic cells, and α 2 Macroglobulin mediated clearance of secreted amyloid precursor protein found in Alzheimer patients. The single chain receptor undergoes cleavage, shortly after synthesis, into the 85 kDa transmembrane β chain that non-covalently binds to the extracellular 500-515 kDa a chain. It has a broad cellular distribution, but in the hematopoietic system it is expressed on monocyte lineage cells. α 2M/LRP-1 mediates endocytosis of a variety of ligands including α 2M-proteinase complexes, plasminogen activators in complex with plasminogen activator inhibitor, or Pseudomonas Exotoxin A. Ligand binding to α 2M/LRP-1 is followed by rapid transport of the ligand to lysosomes for degradation. |
| 别名 | Alpha-2-macroglobulin receptor; α2MR; LRP-1; LDL Receptor-Related Protein-1 |
| 同种亚型 | IgG1,κ |
| 反应种属 | Human (QC Testing) |
| 来源宿主 | Mouse |
| 使用方法 | FC |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Purified Human α2 Macroglobulin |
| 标记 | PE |
| 存放说明 | Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.
|
| 存储溶液 | Aqueous buffered solution containing BSA and ≤0.09% sodium azide. |
