Hu Act Mac-1 (CD11b) BV421 CBRM1/5 25Tst
货号：
566314 基本售价：
3500.0 元 规格：
25TST
产品信息
概述| 货号 | 566314 |
| 描述 | The CBRM1/5 monoclonal antibody specifically recognizes an activated form of the CD11b molecule that is expressed on activated monocytes, granulocytes, NK cells, and subsets of T and B cells. CD11b is also known as the alpha chain of either Mac-1 (MAC-1A/Mac-1 α ) or Complement receptor 3 (CR3A). CD11b is a ~165 kDa type I transmembrane glycoprotein that is encoded by ITGAM (Integrin alpha M). CD11b associates with CD18 (Integrin beta 2) to form the CD11b/CD18 complex, which is also known as the Mac-1 integrin or the Complement receptor 3 (CR3). CD11b functions in cell-cell and cell-substrate interactions involved in leucocyte activation, adhesion, migration, phagocytosis, and other effector functions. CD11b/CD18 serves as a receptor for multiple ligands including iC3b, CD50 (ICAM-3), CD54 (ICAM-1), CD102 (ICAM-2), and fibrinogen. The CBRM1/5 reportedly inhibits Mac-1-dependent adhesion of stimulated neutrophils to CD54 or fibrinogen. |
| 别名 | MAC-1A; Mac-1; ITGAM; Integrin alpha M; CR3A; CR-3 alpha; Mo1; SLEB6 |
| 同种亚型 | Mouse BALB/c IgG1, κ |
| 反应种属 | Human (QC Testing) |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human Mac-1 Protein |
| 存放说明 | Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated with BD Horizon™ BV421 under optimum conditions, and unconjugated antibody and free BD Horizon™ BV421 were removed.
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| 存储溶液 | Aqueous buffered solution containing BSA and ≤0.09% sodium azide. |
