Hu Bik Pure C33-1 100ug
货号：
557040 基本售价：
3484.0 元 规格：
100ug
产品信息
概述| 货号 | 557040 |
| 描述 | Members of the Bcl-2 (B-cell lymphoma-2) family play a major role in regulating the response of cells to apoptotic signals. Several of these proteins function as inhibitors of cell death (e.g., Bcl-2 and Bcl-XL), while others promote cell death (e.g., Bcl-XS, Bax and Bad). Members of this family contain conserved domains, designated BH1, BH2 and BH3, which facilitate protein-protein interactions. Differential interaction among Bcl-2 proteins, as well as their interaction with other cellular or viral proteins, can regulate whether a cell undergoes, or is protected from, an apoptotic death. For example, Bcl-2 normally blocks cell death by forming heterodimers with the pro-apoptotic proteins Bax and Bak. Bcl-2 Interacting Killer (Bik, also known as Nbk) is a novel human protein which is functionally homologous to pro-apoptotic members of the Bcl-2 family. Bik contains the BH3 conserved domain common to Bcl-2 proteins, but lacks either BH1 or BH2 conserved domains. Bik has been reported to interact with and antagonize the activity of anti-apoptotic proteins including Bcl-2, Bcl-X4 as well as the viral proteins Epstein Barr BHRF1 and adenovirus E1B-19K. Blk, a mouse protein which is structurally and functionally homologous to human Bik, has also been identified. In the mouse system, Blk appears to induce apoptosis by activation of caspase-9. |
| 别名 | Bcl-2 Interacting Killer; Nbk |
| 同种亚型 | IgG1 |
| 反应种属 | Human (QC Testing) |
| 来源宿主 | Mouse |
| 使用方法 | WB |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human Bik aa. 40-114 |
| 存放说明 | Store undiluted at 4°C.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
|
| 存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide. |
| 浓度 | 0.5 mg/ml |
