Hu CD140a BB515 aR1 50Tst
货号：
564594 基本售价：
3445.0 元 规格：
50Tst
产品信息
概述| 货号 | 564594 |
| 描述 | The αR1 monoclonal antibody specifically binds to the human platelet derived growth factor (PDGF) receptor α (PDGFR α ), also known as CD140a. CD140a is a 170 kDa single transmembrane glycoprotein expressed on fibroblasts, smooth muscle cells, glial cells a nd chondrocytes. PDGF receptors α and β are single glycoproteins with intracellular tyrosine kinase domains. They are structurally similar to the M-CSF receptor and CD117 (c-kit). Their ligand, PDGF, is a mitogen for connective tissue cells and glial cells. PDGF plays a role in wound healing and it also acts as a chemoattractant for fibroblasts, smooth muscle cells, glial cells, monocytes and neutrophils. Functional PDGF is secreted in disulfide linked, homodimeric or heterodimeric forms comprised of A or B chains (PDGFAA, PDGF-BB or PDGF-AB). Binding of divalent PDGF induces receptor dimerization with three possible form s: αα, αβ, ββ. The PD GFRα subunit binds both PDGF A and B chains, whereas the PDGFR β subunit binds only PDGF B chains. Although both receptor subunits can stimulate mitogenic responses, only the β subunit can induce chemotaxis. TheαR1 antibody is specific for PDGFR α and does not crossreact with PDGFR β . It immunoprecipitates human, monkey, rabbit, pig, dog and cat PDGFR α . It does not recognize hamster, rat or mouse PDGFR α. |
| 别名 | PDGF Receptor α; PDGFRA; PDGFRα; PDGF-R-alpha; PDGFR2; PGFRA; RHEPDGFRA |
| 同种亚型 | Mouse BALB/c IgG2a, κ |
| 反应种属 | Human (QC Testing) |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human PDGFRα Transfected Cell Line |
| 标记 | BB515 |
| 存放说明 | Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated with BD Horizon™ BB515 under optimum conditions and unconjugated antibody was removed.
|
| 存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide. |
