HU GALECTIN-9 PE 9M1-3 25TST
货号：
565892 基本售价：
3427.0 元 规格：
25Tst
产品信息
概述| 货号 | 565892 |
| 描述 | The 9M1-3 monoclonal antibody specifically binds to Galectin-9 (Gal-9) which is encoded by LGALS9 (lectin, galactoside-binding, soluble, 9). Galectin-9 is differentially expressed within or on the surface of various cell types including lymphocytes, macrophages, astrocytes, mast cells, eosinophils, fibroblasts, and endothelial cells. Its expression can be induced by cells in response to proinflammatory cytokines or infection by certain viruses. Galectin-9 is an ~ 50kDa S-type lectin that has two carbohydrate recognition domains (CRDs). It binds to β -galactosides and can serve as a ligand for TIM-3 (CD366). Cell-surface or released forms of Galectin-9 can play multiple roles in innate and adaptive immune responses including the activation of macrophage cytokine secretion, promotion of dendritic cell maturation and regulatory T cell expansion, and negative regulation of Th1, Th17, NK, and cytotoxic T cells. Galectin-9 may contribute to the survival and growth of some tumors by suppressing anti-tumor immune responses. The 9M1-3 antibody reportedly binds to the CRD2 domain of Galectin-9 and can block its binding to TIM-3. |
| 别名 | galectin 9; Gal-9; Ecalectin; HUAT; LGALS9; LEG9; Tumor antigen HOM-HD-21 |
| 同种亚型 | Mouse IgG1, κ |
| 反应种属 | Human (QC Testing) |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human Galectin-9 (AA 208-215) Peptide |
| 标记 | PE |
| 存放说明 | Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.
|
| 存储溶液 | Aqueous buffered solution containing BSA and ≤0.09% sodium azide. |
