Hu CD91 FITC A2MR-A2 100Tst
货号：
550496 基本售价：
3185.0 元 规格：
100Tst
产品信息
概述| 货号 | 550496 |
| 描述 | Reacts with a 600 kDa, type I membrane single protein, also known as the α2 Macroglobulin (α2M) receptor/low density lipoprotein receptor-related protein 1 (LRP-1). Reported to be an endocytic receptor involved with intracellular signalling, lipid homeostasis, clearance of apoptotic cells, and α2 Macroglobulin mediated clearance of secreted amyloid precursor protein found in Alzheimer patients. The single chain receptor undergoes cleavage, shortly after synthesis, into the 85 kDa transmembrane β chain that non-covalently binds to the extracellular 500-515 kDa a chain. It has a broad cellular distribution, but in the hematopoietic system it is expressed on monocyte lineage cells. α2M/LRP-1 mediates endocytosis of a variety of ligands including α2M-proteinase complexes, plasminogen activators in complex with plasminogen activator inhibitor,or Pseudomonas Exotoxin A. Ligand binding to α2M/LRP-1 is followed by rapid transport of the ligand to lysosomes for degradation. |
| 别名 | Alpha-2-macroglobulin receptor; α2MR; LRP-1; LDL Receptor-Related Protein-1 |
| 同种亚型 | IgG1,κ |
| 反应种属 | Human (QC Testing) |
| 来源宿主 | Mouse |
| 使用方法 | FC |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Purified Human α2 Macroglobulin |
| 标记 | FITC |
| 存放说明 | Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated with FITC under optimum conditions, and unreacted FITC was removed.
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| 存储溶液 | Aqueous buffered solution containing BSA and ≤0.09% sodium azide. |
