Hu IL-31 PE U26-947 50Tst
货号：
566326 基本售价：
3120.0 元 规格：
50Tst
产品信息
概述| 货号 | 566326 |
| 描述 | The U26-947 monoclonal antibody specifically binds to Interleukin-31 (IL-31). IL-31 belongs to the IL-6 family of cytokines. It is primarily produced by activated type-2 helper T cells (Th2 cells) and skin-homing cutaneous lymphocyte-associated antigen (CLA)-positive T cells in individuals with atopic dermatitis. IL-31 binds to a heterodimeric cell surface receptor comprised of an IL-31 Receptor alpha subunit (IL-31R α ) and Oncostatin M Receptor beta subunit (OSMR β ). The IL-31 Receptor complex is variably expressed on epithelial cells, keratinocytes, monocytes, macrophages, or eosinophils. IL-31 signaling through the Jak/STAT pathway may induce the release of proinflammatory cytokines including IL-1 beta (IL-1β), IL-6, IL-8, CXCL1 (GRO1α ), and CCL2 (MCP-1). Overexpressed IL-31 may be detected in individuals with allergic asthma, allergic rhinitis, or atopic dermatitis. |
| 别名 | Interleukin-31; Interleukin 31; IL31 |
| 同种亚型 | Mouse BALB/c IgG2a, κ |
| 反应种属 | Human (QC Testing) |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human IL-31 Recombinant Protein |
| 存放说明 | Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.
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| 存储溶液 | Aqueous buffered solution containing BSA and ≤0.09% sodium azide. |
