Hu SOD Pure G215-1 100ug
货号：
556360 基本售价：
2970.0 元 规格：
100ug
产品信息
概述| 货号 | 556360 |
| 描述 | The superoxide free radical O2.- is an intermediate form of molecular oxygen that is produced as a natural by-product of respiration and other biological processes Free radicals like O2.- can lead to the formation of additional reactive oxygen species that, in turn, can cause oxidative damage to DNA, protein, and lipid. The superoxide dismutases provide a defense against the damaging effects of O2.- by converting it to O2 + H2O2 (hydrogen peroxide). Hydrogen peroxide is then normally converted to water by either glutathione peroxidase or catalase. SODs are divided up into three types, and thought to evolve from two independent evolutionary lines: The copper- and zinc-containing SOD, CuZnSOD, is expressed in the cytosol of eukaryotic cells; the manganese-containing SOD, MnSOD, is present in bacteria, in the matrix of bacteria, and in mitochondria; and the iron-containing SOD, FeSOD, is found primarily in bacteria and is also expressed in some plants. All of the SODs catalyze the dismutation of O2.- at approximately the same rates. CuZnSOD lacks amino acid sequence homology with MnSOD and FeSOD, suggesting that it evolved independently from the FeSOD/MnSOD family of enzymes. Mutations have been described in the gene encoding CuZnSOD (SOD1) which reduce the activity and halflife of the enzyme. However, the role of these mutations in pathogenesis remains to be elucidated. Clone G215-1 recognizes human CuZnSOD. The antibody was originally characterized by western blot analysis of cells from transgenic mice expressing human CuZnSOD. Recombinant full-length human CuZnSOD GST fusion protein was used as immunogen. |
| 别名 | CuZnSOD Copper/Zinc-Binding Superoxide Dismutase |
| 同种亚型 | IgG2a |
| 反应种属 | Human (QC Testing) |
| 来源宿主 | Mouse |
| 使用方法 | WB |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Recombinant Human CuZnSOD GST Fusion Protein |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at 4°C.
|
| 存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide. |
| 浓度 | 0.5 mg/ml |
