Microarray-based kinetic colorimetric detection for quantitative multiplex protein phosphorylation analysis.
Authors: Holenya P, Kitanovic I, Heigwer F, Wolfl S
Proteomics, 2011;11(10):2129-33.
Species: Human
Sample Type: recombinant p p38alpha

CXCR4 and CCR5 ligands cooperate in monocyte and lymphocyte migration and in inhibition of dual-tropic (R5/X4) HIV-1 infection.
Authors: Gouwy M, Struyf S, Berghmans N, Vanormelingen C, Schols D, Van Damme J
Eur. J. Immunol., 2011;41(4):963-73.
Species: Human
Sample Type: Cell Lysates

Distinctive ERK and p38 signaling in remote and infarcted myocardium during post-MI remodeling in the mouse.
Authors: Yeh CC, Li H, Malhotra D, Turcato S, Nicholas S, Tu R, Zhu BQ, Cha J, Swigart PM, Myagmar BE, Baker AJ, Simpson PC, Mann MJ
J. Cell. Biochem., 2010;109(6):1185-91.
Species: Mouse
Sample Type: Tissue Homogenates

KR-003048, a potent, orally active inhibitor of p38 mitogen-activated protein kinase.
Authors: Montalban AG, Boman E, Chang CD, Ceide SC, Dahl R, Dalesandro D, Delaet NG, Erb E, Ernst J, Gibbs A, Kahl J, Kessler L, Lundstrom J, Miller S, Nakanishi H, Roberts E, Saiah E, Sullivan R, Wang Z, Larson CJ
Eur. J. Pharmacol., 2010;632(1):93-102.
Species: Human
Sample Type: Cell Lysates

Mechanism of the salutary effects of estrogen on kupffer cell phagocytic capacity following trauma-hemorrhage: pivotal role of Akt activation.
Authors: Hsieh CH, Nickel EA, Chen J, Schwacha MG, Choudhry MA, Bland KI, Chaudry IH
J. Immunol., 2009;182(7):4406-14.
Species: Mouse
Sample Type: Cell Lysates

Enhanced IL-1beta-induced IL-8 production in cystic fibrosis lung epithelial cells is dependent of both mitogen-activated protein kinases and NF-kappaB signaling.
Authors: Muselet-Charlier C, Roque T, Boncoeur E, Chadelat K, Clement A, Jacquot J, Tabary O
Biochem. Biophys. Res. Commun., 2007;357(2):402-7.
Species: Human
Sample Type: Cell Lysates

Low dose leflunomide activates PI3K/Akt signalling in erythroleukemia cells and reduces apoptosis induced by anticancer agents.
Authors: Leger DY, Liagre B, Beneytout JL
Apoptosis, 2006;11(10):1747-60.
Species: Human
Sample Type: Cell Lysates

Cocaethylene affects human microvascular endothelial cell p38 mitogen-activated protein kinase activation and nuclear factor-kappaB DNA-binding activity.
Authors: Tacker DH, Herzog NK, Okorodudu AO
Clin. Chem., 2006;52(10):1926-33.
Species: Human
Sample Type: Cell Lysates

Effects of the active metabolite of leflunomide, A77 1726, on cytokine release and the MAPK signalling pathway in human rheumatoid arthritis synoviocytes.
Authors: Vergne-Salle</LastName><F P</Initial, Vergne-Salle P, Leger DY, Bertin P, Treves R, Beneytout JL, Liagre B
Cytokine, 2005;31(5):335-48.
Species: Human
Sample Type: Cell Lysates

Chondrocyte response to growth factors is modulated by p38 mitogen-activated protein kinase inhibition.
Authors: Studer RK, Bergman R, Stubbs T, Decker K
Arthritis Res. Ther., 2004;6(1):R56-R64.
Species: Rabbit
Sample Type: Cell Lysates

The p38 Mitogen-activated Protein Kinases (MAPKs) are a family of four related Ser/Thr kinases activated by proinflammatory cytokines and environmental stresses. All four p38 family members, alpha, beta, gamma, and delta, are phosphorylated by MKK3 and/or MKK6 at dual Thr and Tyr positions within the phosphoacceptor sequence Thr-Gly-Tyr. Once activated, p38 phosphorylates a number of targets, including the nuclear transcription factors ATF2 and Max.

The most frequently analyzed family member, p38 alpha, also known as SAPK2a and MAPK14, was initially purified as a kinase critical to the signaling cascade linking IL-1 to MAPKAPK-2 and the small heat shock protein HSP27. Ubiquitously expressed, p38 alpha is dually phosphorylated by MKK3 and MKK6 at Thr180 and Tyr182. Once activated, p38 alpha phosphorylates a number of targets, including the cytoplasmic kinases MNK 4 and PRAK5 and the nuclear transcription factors ATF2 1 and STAT1. Several promising compounds that inhibit p38 alpha are being investigated as potential therapies for arthritic and inflammatory diseases.