Rat Agrin DuoSet ELISA, 15 Plate (1 KT)
货号：
DY550 基本售价：
10120.7 元 规格：
1 KIT
产品信息
概述| 货号 | DY550 |
| 别名 | agrin proteoglycan; Agrin; AGRN |
| 反应种属 | Rat |
| 目标/特异性 | Please see the product datasheet |
性能| 供应商 | R&D Systems |
| 检测类型 | Solid Phase Sandwich ELISA |
| Entrez Gene IDs | 375790 (Human); 25592 (Rat); |
| 背景 | Agrin is a 400-600 kDa heparan sulfate proteoglycan component of the extracellular matrix. Multiple forms of are generated by alternative splicing and proteolytic cleavage. Agrin binds to BMP-2, BMP-4, and TGF-beta, and it blocks BMP-induced signaling through BMPR-IA. Agrin binds to a complex of alpha-Dystroglycan, MuSK, and LRP4 on myotubes and induces the clustering of AChR and motoneuron-myotube adhesion at the neuromuscular junction. It binds the Abeta (1-40) peptide in Alzheimer’s disease plaques, promotes amyloid fibril formation, and regulates neuronal excitability. It also binds the gp41 coat protein of HIV-1 and functions as an epithelial cell-virus attachment receptor. During T cell activation, Agrin contributes to formation of the immunological synapse and regulates the threshold of T cell activation. Agrin is upregulated in hepocellular carcinoma, where it enhances cell proliferation and tumor progression. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
