| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Muscle hyperalgesia induced by peripheral P2X3 receptors is modulated by inflammatory mediators.
Authors: Schiavuzzo J, Teixeira J, Melo B, da Silva dos Santos D, Jorge C, Oliveira-Fusaro M, Parada C
Neuroscience, 2015;285(0):24-33.
Species: Rat
Sample Type: Tissue Homogenates
S-nitrosoglutathione accelerates recovery from 5-fluorouracil-induced oral mucositis.
Authors: Skeff M, Brito G, de Oliveira M, Braga C, Cavalcante M, Baldim V, Holanda-Afonso R, Silva-Boghossian C, Colombo A, Ribeiro R, Moura-Neto V, Leitao R
PLoS ONE, 2014;9(12):e113378.
Species: Hamster
Sample Type: Tissue Homogenates
Protective effect of hypercapnic acidosis in ischemia-reperfusion lung injury is attributable to upregulation of heme oxygenase-1.
Authors: Wu S, Li M, Ko F, Wu G, Huang K, Chu S
PLoS ONE, 2013;8(9):e74742.
Species: Rat
Sample Type: BALF
The lectin-like domain of tumor necrosis factor improves lung function after rat lung transplantation--potential role for a reduction in reactive oxygen species generation.
Authors: Hamacher J, Stammberger U, Roux J, Kumar S, Yang G, Xiong C, Schmid RA, Fakin RM, Chakraborty T, Hossain HM, Pittet JF, Wendel A, Black SM, Lucas R
Crit. Care Med., 2010;38(3):871-8.
Species: Rat
Sample Type: BALF
TNF-alpha, IL-1beta, IL-6, and cinc-1 levels in rat brain after meningitis induced by Streptococcus pneumoniae.
Authors: Barichello T, dos Santos I, Savi GD, Simoes LR, Silvestre T, Comim CM, Sachs D, Teixeira MM, Teixeira AL, Quevedo J
J. Neuroimmunol., 2010;221(1):42-5.
Species: Rat
Sample Type: Tissue Homogenates
Supernatant of stored platelets causes lung inflammation and coagulopathy in a novel in vivo transfusion model.
Authors: Vlaar AP, Hofstra JJ, Kulik W
Blood, 2010;116(8):1360-8.
Species: Rat
Sample Type: Tissue Homogenates
Depot-specific modulation of adipokine levels in rat adipose tissue by diet-induced obesity: the effect of aerobic training and energy restriction.
Authors: Yamashita AS, Lira FS, Rosa JC, Paulino EC, Brum PC, Negrao CE, dos Santos RV, Batista ML, do Nascimento CO, Oyama LM, Seelaender M
Cytokine, 2010;52(3):168-74.
Species: Rat
Sample Type: Tissue Homogenates
Effects of ciliary muscle plasmid electrotransfer of TNF-alpha soluble receptor variants in experimental uveitis.
Authors: Touchard E, Bloquel C, Bigey P, Kowalczuc L, Jonet L, Thillaye-Goldenberg B, Naud MC, Scherman D, de Kozak Y, Benezra D, Behar-Cohen F
Gene Ther., 2009;16(7):862-73.
Species: Rat
Sample Type: ocular fluid
Augmentation of endogenous cannabinoid tone modulates lipopolysaccharide-induced alterations in circulating cytokine levels in rats.
Authors: Roche M, Kelly JP, ODriscoll M, ODriscoll M, Finn DP
Immunology, 2008;125(2):263-71.
MAPKs are key players in mediating cytokine release and cell death induced by unconjugated bilirubin in cultured rat cortical astrocytes.
Authors: Fernandes A, Falcao AS, Silva RF, Brito MA, Brites D
Eur. J. Neurosci., 2007;25(4):1058-68.
Species: Rat
Sample Type: Cell Culture Supernates
Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA/p65 NF-kappaB in macrophages in vitro and in rat lungs in vivo: implications for chronic inflammation and aging.
Authors: Yang SR, Wright J, Bauter M, Seweryniak K, Kode A, Rahman I
Am. J. Physiol. Lung Cell Mol. Physiol., 2007;292(2):L567-76.
Species: Rat
Sample Type: BALF
Role of matrix metalloproteinases in the inflammatory response in human airway cell-based assays and in rodent models of airway disease.
Authors: Birrell MA, Wong S, Dekkak A, De Alba J, Haj-Yahia S, Belvisi MG
J. Pharmacol. Exp. Ther., 2006;318(2):741-50.
Species: Rat
Sample Type: BALF
Inflammatory signalling pathways involved in astroglial activation by unconjugated bilirubin.
Authors: Fernandes A, Falcao AS, Silva RF, Gordo AC, Gama MJ, Brito MA, Brites D
J. Neurochem., 2006;96(6):1667-79.
Species: Rat
Sample Type: Cell Culture Supernates
Cardiomyocyte function after burn injury and lipopolysaccharide exposure: single-cell contraction analysis and cytokine secretion profile.
Authors: Niederbichler AD, Westfall MV, Su GL, Donnerberg J, Usman A, Vogt PM, Ipaktchi KR, Arbabi S, Wang SC, Hemmila MR
Shock, 2006;25(2):176-83.
Species: Rat
Sample Type: Cell Culture Supernates
Utility of exhaled nitric oxide as a noninvasive biomarker of lung inflammation in a disease model.
Authors: Birrell MA, McCluskie K, Hardaker E, Knowles R, Belvisi MG
Eur. Respir. J., 2006;28(6):1236-44.
Species: Rat
Sample Type: BALF
Effects of estradiol on lipopolysaccharide and Pam3Cys stimulation of CCL20/macrophage inflammatory protein 3 alpha and tumor necrosis factor alpha production by uterine epithelial cells in culture.
Authors: Crane-Godreau MA, Wira CR
Infect. Immun., 2005;73(7):4231-7.
Species: Human
Sample Type: Cell Culture Supernates
GM-CSF action in the CNS decreases food intake and body weight.
Authors: Reed JA, Clegg DJ, Smith KB, Tolod-Richer EG, Matter EK, Picard LS, Seeley RJ
J. Clin. Invest., 2005;115(11):3035-44.
Species: Rat
Sample Type: Serum
CCL20/macrophage inflammatory protein 3alpha and tumor necrosis factor alpha production by primary uterine epithelial cells in response to treatment with lipopolysaccharide or Pam3Cys.
Authors: Crane-Godreau MA, Wira CR
Infect. Immun., 2005;73(1):476-84.
Species: Rat
Sample Type: Cell Culture Supernates
Maternal poly I:C exposure during pregnancy regulates TNF alpha, BDNF, and NGF expression in neonatal brain and the maternal-fetal unit of the rat.
Authors: Gilmore JH, Jarskog LF, Vadlamudi S
J. Neuroimmunol., 2004;159(1):106-12.
Species: Rat
Sample Type: Tissue Homogenates
A study of the biologic activity of trauma-hemorrhagic shock mesenteric lymph over time and the relative role of cytokines.
Authors: Davidson MT, Deitch EA, Lu Q, Osband A, Feketeova E, Nemeth ZH, Hasko G, Xu DZ
Surgery, 2004;136(1):32-41.
Species: Rat
Sample Type: Mesenteric Lymph Fluid
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| 背景 | Tumor necrosis factor alpha (TNF-α), also known as cachectin and TNFSF2, is the prototypic ligand of the TNF superfamily. It is a pleiotropic molecule that plays a central role in inflammation, apoptosis, and immune system development. TNF-α is produced by a wide variety of immune and epithelial cell types. Human TNF-α consists of a 35 amino acid (aa) cytoplasmic domain, a 21 aa transmembrane segment, and a 177 aa extracellular domain (ECD). Within the ECD, human TNF-α shares 97% aa sequence identity with rhesus and 71% - 92% with bovine, canine, cotton rat, equine, feline, mouse, porcine, and rat TNF-α. The 26 kDa type 2 transmembrane protein is assembled intracellularly to form a noncovalently linked homotrimer. Ligation of this complex induces reverse signaling that promotes lymphocyte costimulation but diminishes monocyte responsiveness. Cleavage of membrane bound TNF-α by TACE/ADAM17 releases a 55 kDa soluble trimeric form of TNF-α. TNF-α trimers bind the ubiquitous TNF RI and the hematopoietic cell-restricted TNF RII, both of which are also expressed as homotrimers. TNF-α regulates lymphoid tissue development through control of apoptosis. It also promotes inflammatory responses by inducing the activation of vascular endothelial cells and macrophages. TNF-α is a key cytokine in the development of several inflammatory disorders. It contributes to the development of type 2 diabetes through its effects on insulin resistance and fatty acid metabolism. |
