Alternatively Activated Mononuclear Phagocytes from the Skin Site of Infection and the Impact of IL-4R? Signalling on CD4+T Cell Survival in Draining Lymph Nodes after Repeated Exposure to Schistosoma mansoni Cercariae
PLoS Negl Trop Dis, 2016;10(8):e0004911.
Species: Mouse
Sample Type: Cell Culture Supernates

Non-canonical interleukin 23 receptor complex assembly: p40 protein recruits interleukin 12 receptor beta1 via site II and induces p19/interleukin 23 receptor interaction via site III.
Authors: Schroder J, Moll J, Baran P, Grotzinger J, Scheller J, Floss D
J Biol Chem, 2015;290(1):359-70.

Overexpression of IL-15 promotes tumor destruction via NK1.1+ cells in a spontaneous breast cancer model.
Authors: Gillgrass A, Chew M, Krneta T, Ashkar A
BMC Cancer, 2015;15(0):293.
Species: Mouse
Sample Type: Tissue Homgenates

MyD88 signalling in myeloid cells is sufficient to prevent chronic mycobacterial infection.
Authors: Berod L, Stuve P, Swallow M, Arnold-Schrauf C, Kruse F, Gentilini M, Freitag J, Holzmann B, Sparwasser T
Eur J Immunol, 2014;44(5):1399-409.
Species: Mouse
Sample Type: Serum

Macrophage Dectin-1 Expression Is Controlled by Leukotriene B4 via a GM-CSF/PU.1 Axis.
Authors: Serezani CH, Kane S, Collins L
J. Immunol., 2012;189(2):906-15.
Species: Mouse
Sample Type: BALF

TLR9 and MyD88 are crucial for the development of protective immunity to malaria.
Authors: Gowda NM, Wu X, Gowda DC
J. Immunol., 2012;188(10):5073-85.
Species: Mouse
Sample Type: Cell Culture Supernates

CD4 T cells promote rather than control tuberculosis in the absence of PD-1-mediated inhibition.
Authors: Barber DL, Mayer-Barber KD, Feng CG
J. Immunol., 2011;186(3):1598-607.
Species: Mouse
Sample Type: BALF

A critical role for C5L2 in the pathogenesis of experimental allergic asthma.
Authors: Zhang X, Schmudde I, Laumonnier Y, Pandey MK, Clark JR, Konig P, Gerard NP, Gerard C, Wills-Karp M, Kohl J
J. Immunol., 2010;185(11):6741-52.
Species: Mouse
Sample Type: Cell Culture Supernates

A conjugated linoleic acid-enriched beef diet attenuates lipopolysaccharide-induced inflammation in mice in part through PPARgamma-mediated suppression of toll-like receptor 4.
Authors: Reynolds CM, Draper E, Keogh B, Rahman A, Moloney AP, Mills KH, Loscher CE, Roche HM
J. Nutr., 2009;139(12):2351-7.
Species: Mouse
Sample Type: Serum

Chorionic gonadotropin alleviates thioglycollate-induced peritonitis by affecting macrophage function.
Authors: Wan H, Coppens JM, van Helden-Meeuwsen CG, Leenen PJ, Van Rooijen N, Khan NA, Kiekens RC, Benner R, Versnel MA
J. Leukoc. Biol., 2009;86(2):361-70.
Species: Mouse
Sample Type: Peritoneal Lavage

Administration of a synthetic TLR4 agonist protects mice from pneumonic tularemia.
Authors: Lembo A, Pelletier M, Iyer R, Timko M, Dudda JC, West TE, Wilson CB, Hajjar AM, Skerrett SJ
J. Immunol., 2008;180(11):7574-81.
Species: Mouse
Sample Type: Tissue Homogenates

Decreased pathology and prolonged survival of human DC-SIGN transgenic mice during mycobacterial infection.
Authors: Schaefer M, Reiling N, Fessler C, Stephani J, Taniuchi I, Hatam F, Yildirim AO, Fehrenbach H, Walter K, Ruland J, Wagner H, Ehlers S, Sparwasser T
J. Immunol., 2008;180(10):6836-45.
Species: Mouse
Sample Type: Cell Culture Supernates

Altered inflammatory responses in TLR5-deficient mice infected with Legionella pneumophila.
Authors: Hawn TR, Berrington WR, Smith IA, Uematsu S, Akira S, Aderem A, Smith KD, Skerrett SJ
J. Immunol., 2007;179(10):6981-7.
Species: Mouse
Sample Type: Tissue Homogenates

Differential involvement of TLR2 and TLR4 in host survival during pulmonary infection with Chlamydia pneumoniae.
Authors: Rodriguez N, Wantia N, Fend F, Durr S, Wagner H, Miethke T
Eur. J. Immunol., 2006;36(5):1145-55.
Species: Mouse
Sample Type: Tissue Homogenates

TLR4 mediates vaccine-induced protective cellular immunity to Bordetella pertussis: role of IL-17-producing T cells.
Authors: Higgins SC, Jarnicki AG, Lavelle EC, Mills KH
J. Immunol., 2006;177(11):7980-9.
Species: Mouse
Sample Type: Cell Culture Supernates

The acylation state of mycobacterial lipomannans modulates innate immunity response through toll-like receptor 2.
Authors: Gilleron M, Nigou J, Nicolle D, Quesniaux V, Puzo G
Chem. Biol., 2006;13(1):39-47.
Species: Mouse
Sample Type: Cell Culture Supernates

MyD88-dependent and -independent murine cytomegalovirus sensing for IFN-alpha release and initiation of immune responses in vivo.
Authors: Delale T, Paquin A, Asselin-Paturel C, Dalod M, Brizard G, Bates EE, Kastner P, Chan S, Akira S, Vicari A, Biron CA, Trinchieri G, Briere F
J. Immunol., 2005;175(10):6723-32.
Species: Mouse
Sample Type: Cell Culture Supernates

Both hemopoietic and resident cells are required for MyD88-dependent pulmonary inflammatory response to inhaled endotoxin.
Authors: Noulin N, Quesniaux VF, Schnyder-Candrian S, Schnyder B, Maillet I, Robert T, Vargaftig BB, Ryffel B, Couillin I
J. Immunol., 2005;175(10):6861-9.
Species: Mouse
Sample Type: BALF

Severe pancreatitis with exocrine destruction and increased islet neogenesis in mice with suppressor of cytokine signaling-1 deficiency.
Authors: Chong MM, Thomas HE, Kay TW
Am. J. Pathol., 2004;165(3):913-21.
Species: Mouse
Sample Type: Serum

Toll-like receptor 2 is required for optimal control of Listeria monocytogenes infection.
Authors: Torres D, Barrier M, Bihl F, Quesniaux VJ, Maillet I, Akira S, Ryffel B, Erard F
Infect. Immun., 2004;72(4):2131-9.
Species: Mouse
Sample Type: Cell Culture Supernates

Fatal Mycobacterium tuberculosis infection despite adaptive immune response in the absence of MyD88.
Authors: Fremond CM, Yeremeev V, Nicolle DM, Jacobs M, Quesniaux VF, Ryffel B
J. Clin. Invest., 2004;114(12):1790-9.
Species: Mouse
Sample Type: Cell Culture Supernates

Stimulation of toll-like receptor 2 by Coxiella burnetii is required for macrophage production of pro-inflammatory cytokines and resistance to infection.
Authors: Zamboni DS, Campos MA, Torrecilhas AC, Kiss K, Samuel JE, Golenbock DT, Lauw FN, Roy CR, Almeida IC, Gazzinelli RT
J. Biol. Chem., 2004;279(52):54405-15.
Species: Mouse
Sample Type: Cell Culture Supernates

Simvastatin augments lipopolysaccharide-induced proinflammatory responses in macrophages by differential regulation of the c-Fos and c-Jun transcription factors.
Authors: Matsumoto M, Einhaus D, Gold ES, Aderem A
J. Immunol., 2004;172(12):7377-84.
Species: Mouse
Sample Type: Cell Culture Supernates

Long-term control of Mycobacterium bovis BCG infection in the absence of Toll-like receptors (TLRs): investigation of TLR2-, TLR6-, or TLR2-TLR4-deficient mice.
Authors: Nicolle D, Fremond C, Pichon X, Bouchot A, Maillet I, Ryffel B, Quesniaux VJ
Infect. Immun., 2004;72(12):6994-7004.
Species: Mouse
Sample Type: Cell Culture Supernates

Cytokine production in association with phagocytosis of apoptotic cells by immature dendritic cells.
Authors: Takahashi M, Kobayashi Y
Cell. Immunol., 2003;226(2):105-15.
Species: Mouse
Sample Type: Cell Culture Supernates

Acylation state of the phosphatidylinositol hexamannosides from Mycobacterium bovis bacillus Calmette Guerin and mycobacterium tuberculosis H37Rv and its implication in Toll-like receptor response.
Authors: Gilleron M, Quesniaux VF, Puzo G
J. Biol. Chem., 2003;278(32):29880-9.
Species: Mouse
Sample Type: Cell Culture Supernates

CpG-DNA aided cross-presentation of soluble antigens by dendritic cells.
Authors: O'Keeffe M
Eur. J. Immunol., 2002;32(8):2356-64.
Species: Mouse
Sample Type: Serum

Reversal of tumor-induced dendritic cell paralysis by CpG immunostimulatory oligonucleotide and anti-interleukin 10 receptor antibody.
Authors: O'Garra A
J. Exp. Med., 2002;196(4):541-9.
Species: Mouse
Sample Type: Cell Culture Supernates

A role for tumor necrosis factor alpha in death of dopaminergic neurons following neural transplantation.
Authors: Clarke DJ, Branton RL
Exp. Neurol., 2002;176(1):154-62.
Species: Mouse
Sample Type: Cell Culture Supernates

Interleukin 12 (IL-12), also known as natural killer cell stimulatory factor (NKSF) or cytotoxic lymphocyte maturation factor (CLMF), is a heterodimeric pleiotropic cytokine made up of a 40 kDa (p40) subunit and a 35 kDa (p35) subunit. The IL-12 p40 subunit is shared by IL-23, another heterodimeric cytokine that has biological activities similar to, as well as distinct from, IL-12. IL-12 is produced by macrophages and B cells and has been shown to have multiple effects on T cells and natural killer (NK) cells. While mouse IL-12 is active on both human and mouse cells, human IL-12 is not active on mouse cells.