| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. NK cells activated by Interleukin-4 in cooperation with Interleukin-15 exhibit distinctive characteristics
Proc Natl Acad Sci USA, 2016;0(0):.
Species: Mouse
Sample Type: Cell Culture Supernates
Cannabinoid receptor 2 modulates susceptibility to experimental cerebral malaria through a CCL17-dependent mechanism
J Biol Chem, 2016;0(0):.
Species: Mouse
Sample Type: Cell Culture Supernates
Citrullinated Vimentin Presented on MHC-II in Tumor Cells Is a Target for CD4+ T-Cell-Mediated Antitumor Immunity.
Authors: Brentville V, Metheringham R, Gunn B, Symonds P, Daniels I, Gijon M, Cook K, Xue W, Durrant L
Cancer Res, 2016;76(3):548-60.
Species: Mouse
Sample Type: Cell Culture Supernates
Lymphocytic Choriomeningitis Virus Expands a Population of NKG2D+CD8+ T Cells That Exacerbates Disease in Mice Coinfected with Leishmania major.
Authors: Crosby E, Clark M, Novais F, Wherry E, Scott P
J Immunol, 2015;195(7):3301-10.
Species: Mouse
Sample Type: Tissue Homogenates
Local immune response to injection of Plasmodium sporozoites into the skin.
Authors: Mac-Daniel L, Buckwalter M, Berthet M, Virk Y, Yui K, Albert M, Gueirard P, Menard R
J Immunol, 2014;193(3):1246-57.
Species: Mouse
Sample Type: Tissue Homogenates
Allogeneic splenocyte transfer and lipopolysaccharide inhalations induce differential T cell expansion and lung injury: a novel model of pulmonary graft-versus-host disease.
Authors: Martinu, Tereza, Kinnier, Christin, Sun, Jesse, Kelly, Francine, Nelson, Margaret, Garantziotis, Stavros, Foster, W Michae, Palmer, Scott M
PLoS ONE, 2014;9(5):e97951.
Species: Mouse
Sample Type: BALF
Engagement of NKG2D on bystander memory CD8 T cells promotes increased immunopathology following Leishmania major infection.
Authors: Crosby E, Goldschmidt M, Wherry E, Scott P
PLoS Pathog, 2014;10(2):e1003970.
Species: Mouse
Sample Type: Tissue Supernates
Plac8-dependent and inducible NO synthase-dependent mechanisms clear Chlamydia muridarum infections from the genital tract.
Authors: Johnson RM, Kerr MS, Slaven JE
J. Immunol., 2012;188(4):1896-904.
Species: Mouse
Sample Type: Cell Culture Supernates
Regulatory T cells expressing granzyme B play a critical role in controlling lung inflammation during acute viral infection.
Authors: Loebbermann J, Thornton H, Durant L
Mucosal Immunol, 2012;5(2):161-72.
Species: Mouse
Sample Type: BALF
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| 背景 | Granzyme family serine proteases are stored in the granules of cytotoxic T lymphocytes and natural killer cells. Granzymes contain one S1 protease domain and are synthesized as preproproteins. Granzymes are released toward pathogen infected or transformed target cells during cellular immune reactions. Target cell entry by granzymes is through perforin channels. Granzymes trigger apoptosis by caspase-dependent and -independent mechanisms. There are five granzymes (A, B, G, H and K) in human and many more in mouse and rat. |
