Human TIMP-2 DuoSet ELISA, 15 Plate (1 KT)【科瑞奥博】

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Human TIMP-2 DuoSet ELISA, 15 Plate (1 KT)

货号： DY971 基本售价： 10120.7 元规格： 1 KIT

产品信息

概述
货号	DY971
别名	CSC-21Ktissue inhibitor of metalloproteinase 2; metalloproteinase inhibitor 2; TIMP metallopeptidase inhibitor 2; TIMP2; TIMP-2; Tissue inhibitor of metalloproteinases 2
全称	Tissue Inhibitors of Metalloproteinases 2
反应种属	Human
目标/特异性	Please see the product datasheet

性能
供应商	R&D Systems
检测类型	Solid Phase Sandwich ELISA
Entrez Gene IDs	7077 (Human); 21858 (Mouse); 29543 (Rat);
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Identification of neutrophil activation markers as novel surrogate markers of CF lung disease. Authors: Rath T, Zwaschka L, Hage L, Kugler M, Menendez K, Naehrlich L, Schulz R, Roderfeld M, Roeb E PLoS ONE, 2014;9(12):e115847. Species: Human Sample Type: Serum Expression of matrix metalloproteinases and their tissue inhibitors in the serum and cerebrospinal fluid of patients with HIV-1 infection and syphilis or neurosyphilis. Authors: Tsai HC, Ye SY, Kunin CM, Lee SS, Wann SR, Tai MH, Shi MH, Liu YC, Chen YS Cytokine, 2011;54(0):109-16. Species: Human Sample Type: CSF High MMP-9 activity characterises pleural tuberculosis correlating with granuloma formation. Authors: Sheen P, OKane CM, OKane CM, Chaudhary K, Tovar M, Santillan C, Sosa J, Caviedes L, Gilman RH, Stamp G, Friedland JS Eur. Respir. J., 2009;33(1):134-41. Species: Human Sample Type: Pleural Fluid Simvastatin decreases lipopolysaccharide-induced pulmonary inflammation in healthy volunteers. Authors: Shyamsundar M, McKeown ST, OKane CM, OKane CM, OKane CM, OKane CM, OKane CM, Craig TR, Brown V, Thickett DR, Matthay MA, Taggart CC, Backman JT, Elborn JS, McAuley DF Am. J. Respir. Crit. Care Med., 2009;179(12):1107-14. Species: Human Sample Type: BALF Matrix metalloproteinases and their tissue inhibitors (TIMPs) in Plasmodium falciparum malaria: serum levels of TIMP-1 are associated with disease severity. Authors: Dietmann A, Helbok R, Lackner P, Issifou S, Lell B, Matsiegui PB, Reindl M, Schmutzhard E, Kremsner PG J. Infect. Dis., 2008;197(11):1614-20. Species: Human Sample Type: Serum Association of matrix metalloproteinase-9 and tissue inhibitors of metalloproteinase-4 in cerebrospinal fluid with blood-brain barrier dysfunction in patients with eosinophilic meningitis caused by Angiostrongylus cantonensis. Authors: Tsai HC, Chung LY, Chen ER, Sy CL Am. J. Trop. Med. Hyg., 2008;78(1):20-7. Species: Human Sample Type: CSF Increased production of matrix metalloproteinases in Helicobacter pylori-associated human gastritis. Authors: Bergin PJ, Anders E, Sicheng W, Erik J, Jennie A, Hans L, Pierre M, Qiang PH, Marianne QJ Helicobacter, 2004;9(0):201. Species: Human Sample Type: Tissue Homogenates
背景	TIMPs-1 through -4 regulate the activity of zinc metalloproteases known as MMPs, ADAMs and ADAMTSs. Structurally, TIMPs contain two domains. The N-terminal domain binds to the active site of mature metalloproteases via a 1:1 non-covalent interaction, blocking access of substrates to the catalytic site. In addition, The C-terminal domain of TIMP-1 and TIMP-2 binds to the hemopexin- like domain of pro-MMP-9 and pro-MMP-2, respectively. The latter binding is essential for the cell surface activation of MMP-2 by MMP-14.
运输条件	Blue Ice
存放说明	4℃