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Human CX3CL1/Fractalkine DuoSet ELISA, 15 Plate (1 KT)

货号: DY365 基本售价: 10120.7 元 规格: 1 KIT

产品信息

概述
货号DY365
别名
ABCD-3; C3Xkine; chemokine (C-X3-C motif) ligand 1; CX3C membrane-anchored chemokine; CX3CL1; CXC3; CXC3C; FKN; Fractalkine; Neurotactin; neurotactin); NTNsmall inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine; NTTSmall-inducible cytokine D1; SCYD1C-X3-C motif chemokine 1; small inducible cytokine subfamily D (Cys-X3-Cys), member-1
反应种属Human
目标/特异性Please see the product datasheet
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs6376 (Human); 20312 (Mouse); 89808 (Rat);
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

CX3CL1 expression in the conjunctiva is involved in immune cell trafficking during toxic ocular surface inflammation.
Authors: Denoyer A, Godefroy D, Celerier I, Frugier J, Riancho L, Baudouin F, Rostene W, Baudouin C
Mucosal Immunol, 2012;5(0):702.
Species: Human
Sample Type: Cell Culture Supernates

Serum level of soluble CX3CL1/fractalkine is elevated in patients with polymyositis and dermatomyositis, which is correlated with disease activity.
Authors: Suzuki F, Kubota T
Arthritis Res. Ther., 2012;14(2):R48.
Species: Human
Sample Type: Serum

Thromboxane prostanoid receptor stimulation induces shedding of the transmembrane chemokine CX3CL1 yet enhances CX3CL1-dependent leukocyte adhesion.
Authors: Tole S, Durkan AM, Huang YW, Liu GY, Leung A, Jones LL, Taylor JA, Robinson LA
Am. J. Physiol., Cell Physiol., 2010;298(6):C1469-80.
Species: Human
Sample Type: Cell Lysates

The involvement of the fractalkine receptor in the transmigration of neuroblastoma cells through bone-marrow endothelial cells.
Authors: Nevo I, Sagi-Assif O, Meshel T, Ben-Baruch A, Johrer K, Greil R, Trejo LE, Kharenko O, Feinmesser M, Yron I, Witz IP
Cancer Lett., 2009;273(1):127-39.
Species: Human
Sample Type: Cell Culture Supernates

Expression of ADAM-17, TIMP-3 and fractalkine in the human adult brain endothelial cell line, hCMEC/D3, following pro-inflammatory cytokine treatment.
Authors: Hurst LA, Bunning RA, Couraud PO, Romero IA, Weksler BB, Sharrack B, Woodroofe MN
J. Neuroimmunol., 2009;210(1):108-12.
Species: Human
Sample Type: Cell Culture Supernates

CX3CR1 is expressed by prostate epithelial cells and androgens regulate the levels of CX3CL1/fractalkine in the bone marrow: potential role in prostate cancer bone tropism.
Authors: Jamieson WL, Shimizu S, DAmbrosio JA, Meucci O, Fatatis A
Cancer Res., 2008;68(6):1715-22.
Species: Human
Sample Type: Tissue Aspirate

Urinary fractalkine is a marker of acute rejection.
Authors: Peng W, Chen J, Jiang Y, Wu J, Shou Z, He Q, Wang Y, Chen Y, Wang H
Kidney Int., 2008;74(11):1454-60.
Species: Human
Sample Type: Urine

Cytokine expression profiling of the myocardium reveals a role for CX3CL1 (fractalkine) in heart failure.
Authors: Husberg C, Nygard S, Finsen AV, Damas JK, Frigessi A, Oie E, Waehre A, Gullestad L, Aukrust P, Yndestad A, Christensen G
J. Mol. Cell. Cardiol., 2008;45(2):261-9.
Species: Human
Sample Type: Serum

Vitamin D and glucocorticoids differentially modulate chemokine expression in human airway smooth muscle cells.
Authors: Banerjee A, Damera G, Bhandare R, Gu S, Lopez-Boado Y, Panettieri R, Tliba O
Br. J. Pharmacol., 2008;155(1):84-92.
Species: Human
Sample Type: Cell Culture Supernates

High T-cell response to human cytomegalovirus induces chemokine-mediated endothelial cell damage.
Authors: Bolovan-Fritts CA, Trout RN, Spector SA
Blood, 2007;110(6):1857-63.
Species: Human
Sample Type: Cell Culture Supernates

Proteomics analysis of Hodgkin lymphoma: identification of new players involved in the cross-talk between HRS cells and infiltrating lymphocytes.
Authors: Ma Y, Visser L, Roelofsen H, de Vries M, Diepstra A, van Imhoff G, van der Wal T, Luinge M, Alvarez-Llamas G, Vos H, Poppema S, Vonk R, Van Den Berg A
Blood, 2007;111(4):2339-46.
Species: Human
Sample Type: Cell Culture Supernates

Endothelial damage from cytomegalovirus-specific host immune response can be prevented by targeted disruption of fractalkine-CX3CR1 interaction.
Authors: Bolovan-Fritts CA, Spector SA
Blood, 2007;111(1):175-82.
Species: Human
Sample Type: Cell Culture Supernates

The uremic solute p-cresol decreases leukocyte transendothelial migration in vitro.
Authors: Faure V, Cerini C, Paul P, Berland Y, Dignat-George F, Brunet P
Int. Immunol., 2006;18(10):1453-9.
Species: Human
Sample Type: Cell Culture Supernates

Soluble fractalkine in the cerebrospinal fluid of patients with neuropsychiatric lupus.
Authors: Sato E, Iikuni N, Yoshio T, Minota S, Kamatani N, Okamoto H
Ann. Rheum. Dis., 2006;65(9):1257-9.
Species: Human
Sample Type: CSF

Fractalkine and CX3CR1 are involved in the recruitment of intraepithelial lymphocytes of intrahepatic bile ducts.
Authors: Isse K, Harada K, Zen Y, Kamihira T, Shimoda S, Harada M, Nakanuma Y
Hepatology, 2005;41(3):506-16.
Species: Human
Sample Type: Serum

Fractalkine reduces N-methyl-d-aspartate-induced calcium flux and apoptosis in human neurons through extracellular signal-regulated kinase activation.
Authors: Deiva K, Geeraerts T, Salim H, Leclerc P, Hery C, Hugel B, Freyssinet JM, Tardieu M
Eur. J. Neurosci., 2004;20(12):3222-32.
Species: Human
Sample Type: Cell Culture Supernates

Human cytomegalovirus-specific CD4+-T-cell cytokine response induces fractalkine in endothelial cells.
Authors: Bolovan-Fritts CA, Trout RN, Spector SA
J. Virol., 2004;78(23):13173-81.
Species: Human
Sample Type: Cell Culture Supernates

背景CX3CL1/Fractalkine is a transmembrane adhesion protein with a chemokine domain separated from the membrane by a mucin stalk. It is upregulated on many cell types during inflammation. The chemokine and mucin regions can be shed as a soluble chemokine that signals through the receptor CX3CR1. During extravasation, membrane-bound CX3CL1 traps leukocytes, then is cleaved to allow diapedesis. Soluble CX3CL1 protects neurons from microglial neurotoxicity, recruits macrophages for wound healing, recruits osteoclast precursors for bone resorption, and contributes to pathogenesis in coronary artery disease.
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