| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Characterization of In Vitro Engineered Human Adipose Tissues: Relevant Adipokine Secretion and Impact of TNF-alpha.
Authors: Aubin K, Safoine M, Proulx M, Audet-Casgrain M, Côté J, Tetu F, Roy A, Fradette J
PLoS ONE, 2015;10(9):e0137612.
Species: Human
Sample Type: Cell Culture Supernates
Transplantation of human adipose tissue-derived stem cells delays clinical onset and prolongs life span in ALS mouse model.
Authors: Kim, Kwang S, Lee, Hong J, An, Jin, Kim, Yun B, Ra, Jung Cha, Lim, Inja, Kim, Seung U
Cell Transplant, 2014;23(12):1585-97.
Species: Human
Sample Type: cell culture supernate
Aqueous two-phase system patterning of detection antibody solutions for cross-reaction-free multiplex ELISA.
Authors: Frampton, John P, White, Joshua B, Simon, Arlyne B, Tsuei, Michael, Paczesny, Sophie, Takayama, Shuichi
Sci Rep, 2014;4(0):4878.
Species: Human
Sample Type: Plasma
Fibroblasts derived from human pluripotent stem cells activate angiogenic responses in vitro and in vivo.
Authors: Shamis Y, Silva E, Hewitt K, Brudno Y, Levenberg S, Mooney D, Garlick J
PLoS ONE, 2013;8(12):e83755.
Species: Human
Sample Type: Cell Culture Supernates
Heparanase Plays a Dual Role in Driving Hepatocyte Growth Factor (HGF) Signaling by Enhancing HGF Expression and Activity.
Authors: Ramani VC, Yang Y, Ren Y
J. Biol. Chem., 2011;286(8):6490-9.
Species: Human
Sample Type: Cell Culture Supernates
Angiogenesis and lymphangiogenesis are downregulated in primary breast cancer.
Authors: Boneberg EM, Legler DF, Hoefer MM, Ohlschlegel C, Steininger H, Fuzesi L, Beer GM, Dupont-Lampert V, Otto F, Senn HJ, Furstenberger G
Br. J. Cancer, 2009;101(4):605-14.
Species: Human
Sample Type: Serum
Bronchial epithelial cell growth regulation in fibroblast cocultures: the role of hepatocyte growth factor.
Authors: Skibinski G, Elborn JS, Ennis M
Am. J. Physiol. Lung Cell Mol. Physiol., 2007;293(1):L69-76.
Species: Human
Sample Type: Cell Culture Supernates
Regulation of hepatocyte growth factor secretion by fibroblasts in patients with acute lung injury.
Authors: Quesnel C, Marchand-Adam S, Fabre A, Marchal-Somme J, Philip I, Lasocki S, Lecon V, Crestani B, Dehoux M
Am. J. Physiol. Lung Cell Mol. Physiol., 2007;294(2):L334-43.
Species: Human
Sample Type: BALF
Influence of microvascular endothelial cells on transcriptional regulation of proximal tubular epithelial cells.
Authors: Aydin S, Signorelli S, Lechleitner T, Joannidis M, Pleban C, Perco P, Pfaller W, Jennings P
Am. J. Physiol., Cell Physiol., 2007;294(2):C543-54.
Species: Human
Sample Type: Cell Culture Supernates
Structural basis of hepatocyte growth factor/scatter factor and MET signalling.
Authors: Gherardi E, Sandin S, Petoukhov MV, Finch J, Youles ME, Ofverstedt LG, Miguel RN, Blundell TL, Vande Woude GF, Skoglund U, Svergun DI
Proc. Natl. Acad. Sci. U.S.A., 2006;103(11):4046-51.
Species: Human
Sample Type: Cell Culture Supernates
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| 背景 | HGF (Hepatocyte Growth Factor, Scatter Factor) induces the proliferation and migration of epithelial cells, hepatocytes, chondrocytes, keratinocytes, melanocytes, endothelial cells, and many tumor cells. During organogenesis and tissue repair, HGF promotes epithelial/endothelial morphogenesis by inducing cell scattering and branching tubulogenesis. It also supports insulin production by pancreatic beta cells, neuronal survival, and immune tolerance. HGF is secreted as a propeptide that is activated by uPA or HGF Activator at sites of tissue damage. Its signaling through the receptor HGF R/c-MET is enhanced by its prior binding to heparan sulfate proteoglycans. The serum levels of HGF are elevated in a wide range of pathologies including liver damage, acute kidney failure, myocardial infarction, type 1 diabetes, obesity, and cancer, as well as in the synovial fluid of rheumatoid arthritis patients. |
